Acute retinal necrosis associated with epstein-barr virus: Immunohistopathologic confirmation

Shlomit Schaal; Aleksandr Kagan; Yujuan Wang; Chi Chao Chan; Henry J. Kaplan

doi:10.1001/jamaophthalmol.2014.266

Acute retinal necrosis associated with epstein-barr virus: Immunohistopathologic confirmation

Shlomit Schaal, Aleksandr Kagan, Yujuan Wang, Chi Chao Chan, Henry J. Kaplan

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

IMPORTANCE: Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation.We report the clinical history and histopathologic confirmation that EBV can cause ARN. OBSERVATIONS: Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. CONCLUSIONS AND RELEVANCE: Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.

Original language	English (US)
Pages (from-to)	881-882
Number of pages	2
Journal	JAMA Ophthalmology
Volume	132
Issue number	7
DOIs	https://doi.org/10.1001/jamaophthalmol.2014.266
State	Published - Jul 2014

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1001/jamaophthalmol.2014.266

Cite this

@article{58065b4040f44043b67eecdaaf2c5f27,

title = "Acute retinal necrosis associated with epstein-barr virus: Immunohistopathologic confirmation",

abstract = "IMPORTANCE: Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation.We report the clinical history and histopathologic confirmation that EBV can cause ARN. OBSERVATIONS: Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. CONCLUSIONS AND RELEVANCE: Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.",

author = "Shlomit Schaal and Aleksandr Kagan and Yujuan Wang and Chan, \{Chi Chao\} and Kaplan, \{Henry J.\}",

year = "2014",

month = jul,

doi = "10.1001/jamaophthalmol.2014.266",

language = "English (US)",

volume = "132",

pages = "881--882",

journal = "JAMA Ophthalmology",

issn = "2168-6165",

publisher = "American Medical Association",

number = "7",

}

TY - JOUR

T1 - Acute retinal necrosis associated with epstein-barr virus

T2 - Immunohistopathologic confirmation

AU - Schaal, Shlomit

AU - Kagan, Aleksandr

AU - Wang, Yujuan

AU - Chan, Chi Chao

AU - Kaplan, Henry J.

PY - 2014/7

Y1 - 2014/7

N2 - IMPORTANCE: Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation.We report the clinical history and histopathologic confirmation that EBV can cause ARN. OBSERVATIONS: Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. CONCLUSIONS AND RELEVANCE: Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.

AB - IMPORTANCE: Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation.We report the clinical history and histopathologic confirmation that EBV can cause ARN. OBSERVATIONS: Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. CONCLUSIONS AND RELEVANCE: Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.

UR - https://www.scopus.com/pages/publications/84901445608

UR - https://www.scopus.com/inward/citedby.url?scp=84901445608&partnerID=8YFLogxK

U2 - 10.1001/jamaophthalmol.2014.266

DO - 10.1001/jamaophthalmol.2014.266

M3 - Article

C2 - 24743882

AN - SCOPUS:84901445608

SN - 2168-6165

VL - 132

SP - 881

EP - 882

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

IS - 7

ER -

Acute retinal necrosis associated with epstein-barr virus: Immunohistopathologic confirmation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this