Acute retinal necrosis associated with epstein-barr virus: Immunohistopathologic confirmation

Shlomit Schaal, Aleksandr Kagan, Yujuan Wang, Chi Chao Chan, Henry J. Kaplan

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


IMPORTANCE: Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation.We report the clinical history and histopathologic confirmation that EBV can cause ARN. OBSERVATIONS: Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. CONCLUSIONS AND RELEVANCE: Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.

Original languageEnglish (US)
Pages (from-to)881-882
Number of pages2
JournalJAMA Ophthalmology
Issue number7
StatePublished - Jul 2014

ASJC Scopus subject areas

  • Ophthalmology


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