Acute Renal Failure during Therapy with Recombinant Human Gamma Interferon

Bettina H. Ault, F. Bruder Stapleton, Lillian Gaber, Alison Martin, Shane Roy, Sharon B. Murphy

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


THE interferons are a group of glycoproteins with antiviral, immunomodulatory, and antitumor activities. There are three major types: alfa (leukocyte or lymphoblastoid), beta (fibroblast), and gamma (immune) interferon. Alfa interferon has proved efficacy in treating various human cancers.12 The gene for gamma interferon has been cloned more recently, and Phase I and II studies in adults have demonstrated it to be capable of producing antitumor effects.34 Interferon-induced renal toxicity is quite unusual, although acute renal failure with interstitial nephritis has been reported in one woman receiving alfa interferon for mycosis fungoides.5 We describe a 12-year-old child in whom acute renal.

Original languageEnglish (US)
Pages (from-to)1397-1400
Number of pages4
JournalNew England Journal of Medicine
Issue number21
StatePublished - Nov 24 1988

ASJC Scopus subject areas

  • Medicine(all)


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