TY - JOUR
T1 - Acute Renal Failure during Therapy with Recombinant Human Gamma Interferon
AU - Ault, Bettina H.
AU - Stapleton, F. Bruder
AU - Gaber, Lillian
AU - Martin, Alison
AU - Roy, Shane
AU - Murphy, Sharon B.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1988/11/24
Y1 - 1988/11/24
N2 - THE interferons are a group of glycoproteins with antiviral, immunomodulatory, and antitumor activities. There are three major types: alfa (leukocyte or lymphoblastoid), beta (fibroblast), and gamma (immune) interferon. Alfa interferon has proved efficacy in treating various human cancers.12 The gene for gamma interferon has been cloned more recently, and Phase I and II studies in adults have demonstrated it to be capable of producing antitumor effects.34 Interferon-induced renal toxicity is quite unusual, although acute renal failure with interstitial nephritis has been reported in one woman receiving alfa interferon for mycosis fungoides.5 We describe a 12-year-old child in whom acute renal.
AB - THE interferons are a group of glycoproteins with antiviral, immunomodulatory, and antitumor activities. There are three major types: alfa (leukocyte or lymphoblastoid), beta (fibroblast), and gamma (immune) interferon. Alfa interferon has proved efficacy in treating various human cancers.12 The gene for gamma interferon has been cloned more recently, and Phase I and II studies in adults have demonstrated it to be capable of producing antitumor effects.34 Interferon-induced renal toxicity is quite unusual, although acute renal failure with interstitial nephritis has been reported in one woman receiving alfa interferon for mycosis fungoides.5 We describe a 12-year-old child in whom acute renal.
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U2 - 10.1056/NEJM198811243192107
DO - 10.1056/NEJM198811243192107
M3 - Article
C2 - 3141812
AN - SCOPUS:0023691392
SN - 0028-4793
VL - 319
SP - 1397
EP - 1400
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -