TY - JOUR
T1 - Acute myelofibrosis
T2 - A report of four cases and review of the literature
AU - Truong, Luan D.
AU - Saleem, Abdus
AU - Schwartz, Mary R.
PY - 1984/5
Y1 - 1984/5
N2 - Four new cases of acute myelofibrosis are reported, and 63 cases reported in the literature are reviewed. The typical features of this disease include a rapidly progressive clinical course: nonspecific symptoms such as weight loss, anorexia, fatigue and weakness; the absence of organomegaly; pancytopenia; circulating blast cells; and mild abnormalities in the red blood cell morphology. The bone marrow aspirates are usually 'dry'. The bone marrow biopsies are essential for the diagnosis and show four consistent features: hypercellularity, reticulin fibrosis, proliferation of blast cells and bizarre, atypical megakaryocytes. In 16 cases, the blast cells in peripheral blood and bone marrow, which are unclassifiable by conventional morphology, could be identified as megakaryoblasts by ultrastructural and immunocytochemical techniques. It is concluded that acute myelofibrosis is a definite clinicopathologic entity, which may be related to acute megakaryoblastic leukemia.
AB - Four new cases of acute myelofibrosis are reported, and 63 cases reported in the literature are reviewed. The typical features of this disease include a rapidly progressive clinical course: nonspecific symptoms such as weight loss, anorexia, fatigue and weakness; the absence of organomegaly; pancytopenia; circulating blast cells; and mild abnormalities in the red blood cell morphology. The bone marrow aspirates are usually 'dry'. The bone marrow biopsies are essential for the diagnosis and show four consistent features: hypercellularity, reticulin fibrosis, proliferation of blast cells and bizarre, atypical megakaryocytes. In 16 cases, the blast cells in peripheral blood and bone marrow, which are unclassifiable by conventional morphology, could be identified as megakaryoblasts by ultrastructural and immunocytochemical techniques. It is concluded that acute myelofibrosis is a definite clinicopathologic entity, which may be related to acute megakaryoblastic leukemia.
UR - http://www.scopus.com/inward/record.url?scp=0021248805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021248805&partnerID=8YFLogxK
U2 - 10.1097/00005792-198405000-00004
DO - 10.1097/00005792-198405000-00004
M3 - Article
C2 - 6371442
AN - SCOPUS:0021248805
VL - 63
SP - 182
EP - 187
JO - Medicine (United States)
JF - Medicine (United States)
SN - 0025-7974
IS - 3
ER -