Acute myelofibrosis - A leukemia of pluripotent stem cell: A report of three cases and review of the literature

D. M. Amberger, A. Saleem, B. L. Kemp, Luan Truong

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The histogenesis of blasts in acute myelofibrosis is generally regarded to be of megakaryocytic origin. Three case reports are presented and 19 other reported cases are reviewed from the literature where the cells of origin appear to be myeloblasts, myelomonoblasts, lymphoblasts, or undifferentiated blasts. It is therefore postulated that acute myelofibrosis is a hemopoietic stem cell disorder, and acute megakaryocytic leukemia (FAB-M7) represents one subset of the disorder.

Original languageEnglish (US)
Pages (from-to)409-414
Number of pages6
JournalAnnals of clinical and laboratory science
Volume20
Issue number6
StatePublished - Dec 1 1990

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

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