Acute myelofibrosis - A leukemia of pluripotent stem cell: A report of three cases and review of the literature

D. M. Amberger; A. Saleem; B. L. Kemp; Luan Truong

Acute myelofibrosis - A leukemia of pluripotent stem cell: A report of three cases and review of the literature

D. M. Amberger, A. Saleem, B. L. Kemp, Luan Truong

Research output: Contribution to journal › Article

Abstract

The histogenesis of blasts in acute myelofibrosis is generally regarded to be of megakaryocytic origin. Three case reports are presented and 19 other reported cases are reviewed from the literature where the cells of origin appear to be myeloblasts, myelomonoblasts, lymphoblasts, or undifferentiated blasts. It is therefore postulated that acute myelofibrosis is a hemopoietic stem cell disorder, and acute megakaryocytic leukemia (FAB-M7) represents one subset of the disorder.

Original language	English (US)
Pages (from-to)	409-414
Number of pages	6
Journal	Annals of clinical and laboratory science
Volume	20
Issue number	6
State	Published - Dec 1 1990

ASJC Scopus subject areas

Microbiology
Immunology and Allergy
Pathology and Forensic Medicine
Immunology
Molecular Biology
Hematology
Clinical Biochemistry
Medical Laboratory Technology

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abstract = "The histogenesis of blasts in acute myelofibrosis is generally regarded to be of megakaryocytic origin. Three case reports are presented and 19 other reported cases are reviewed from the literature where the cells of origin appear to be myeloblasts, myelomonoblasts, lymphoblasts, or undifferentiated blasts. It is therefore postulated that acute myelofibrosis is a hemopoietic stem cell disorder, and acute megakaryocytic leukemia (FAB-M7) represents one subset of the disorder.",

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N2 - The histogenesis of blasts in acute myelofibrosis is generally regarded to be of megakaryocytic origin. Three case reports are presented and 19 other reported cases are reviewed from the literature where the cells of origin appear to be myeloblasts, myelomonoblasts, lymphoblasts, or undifferentiated blasts. It is therefore postulated that acute myelofibrosis is a hemopoietic stem cell disorder, and acute megakaryocytic leukemia (FAB-M7) represents one subset of the disorder.

AB - The histogenesis of blasts in acute myelofibrosis is generally regarded to be of megakaryocytic origin. Three case reports are presented and 19 other reported cases are reviewed from the literature where the cells of origin appear to be myeloblasts, myelomonoblasts, lymphoblasts, or undifferentiated blasts. It is therefore postulated that acute myelofibrosis is a hemopoietic stem cell disorder, and acute megakaryocytic leukemia (FAB-M7) represents one subset of the disorder.

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