Active curcumin nanoparticles formed from a volatile microemulsion template

K. Margulis, S. Srinivasan, M. J. Ware, H. D. Summers, B. Godin, S. Magdassi

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We report on the biological performance of organic nanoparticles formed by a simple method based on rapid solvent removal from a volatile microemulsion. The particular focus of the study was on testing the suitability of the method for substances soluble in partially water-miscible organic solvents as well as on evaluating the therapeutic activity of the resultant nanoparticles. Curcumin was employed as a model for hydrophobic drugs, and, as it is soluble in water-miscible organic solvents, it was successfully incorporated into a new cyclopentanone-water microemulsion system. During rapid solvent removal by spray-drying, the nanometric droplets of the microemulsion were converted into nanoparticles containing amorphous curcumin with an average size of 20.2 ± 3.4 nm, having a ζ potential of -36.2 ± 1.8 mV. These nanoparticles were dispersible in water and retained the high loading of the active substance. The therapeutic activity of the resulting nanoparticles was demonstrated in a pancreatic cancer cell line, PANC-1. The effective concentration for reducing the metabolic activity by 50% (EC50) was found to be 11.5 μM for nanoparticles compared with 19.5 μM for free curcumin. This journal is

Original languageEnglish (US)
Pages (from-to)3745-3752
Number of pages8
JournalJournal of Materials Chemistry B
Volume2
Issue number24
DOIs
StatePublished - Jun 28 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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