Activation of the liver X receptor-β potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrowderived macrophages

Keyphrases

• Macrophages 100%
• Liver X Receptor 100%
• Lipopolysaccharide 100%
• AZD3965 100%
• Osteoclastogenesis 100%
• Exposed Bone 100%
• Osteoclast Differentiation 57%
• Osteoclast 42%
• Reduced Expression 14%
• Interleukin-6 14%
• Inflammatory Cytokines 14%
• Therapeutic Effect 14%
• NF-B 14%
• Interleukin-1β 14%
• LPS-induced Inflammation 14%
• Cytokine Expression 14%
• Osteomyelitis 14%
• Matrix metalloproteinase-9 (MMP-9) 14%
• Inflammatory Pathways 14%
• RAW264.7 Cells 14%
• Chronic Inflammatory Diseases 14%
• Multinucleated 14%
• Bone Destruction 14%
• Bone Disease 14%
• Inhibitory Action 14%
• Bone Erosion 14%
• MAPK p38 14%
• Stamping 14%
• LXR Agonist 14%
• Ctsk 14%
• ACP5 14%
• IL-12p40 14%
• Periodontitis 14%
• Contractile Ring 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Liver X Receptor 100%
• Lipopolysaccharide 100%
• 3 [3 [[2 Chloro 3 (Trifluoromethyl)benzyl](2 Diphenylethyl)amino]propoxy]phenylacetic Acid 100%
• Osteoclast Differentiation Factor 57%
• Cytokine 28%
• Interleukin 6 14%
• Tumor Necrosis Factor 14%
• Therapeutic Effect 14%
• Interleukin 1 14%
• Osteomyelitis 14%
• Inflammatory Disease 14%
• Actin 14%
• Bone Disease 14%
• Bone Erosion 14%
• Periodontitis 14%
• Bone Destruction 14%

Immunology and Microbiology

• Macrophage 100%
• Osteoclastogenesis 100%
• RANKL 66%
• Osteoclast 50%
• Cytokine 16%
• Agonist 16%
• Tumor Necrosis Factor 16%
• Interleukin 6 16%
• Lineage 16%
• Proinflammatory Cytokine 16%
• Interleukin 1 16%
• Actin 16%
• Inflammatory Disorder 16%
• Periodontitis 16%