TY - JOUR
T1 - Activation of sexual behaviour in castrated rats with the synthetic androgen 17β-hydroxy-17α-methyl-estra-4,9,11-triene-3-one (R 1881)
AU - Sodersten, P.
AU - Gustafsson, J. A.
PY - 1980
Y1 - 1980
N2 - Castrated sexually inactive rats were treated with the synthetic androgen 17β-hydroxy-17α-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R 1881), testosterone benzoate (TB), 5α-dihydrotestosterone benzoate (DHTB) or oestradiol benzoate (OB) and tested for sexual behaviour. The synthetic androgen, R 1881, was as potent as TB in stimulating sexual behaviour and OB stimulated all aspects of copulatory behaviour but DHTB had no significant effect. The synthetic androgen, R 1881, is not metabolized by target cells and rapid metabolism could explain the failure of DHTB to stimulate sexual behaviour.
AB - Castrated sexually inactive rats were treated with the synthetic androgen 17β-hydroxy-17α-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R 1881), testosterone benzoate (TB), 5α-dihydrotestosterone benzoate (DHTB) or oestradiol benzoate (OB) and tested for sexual behaviour. The synthetic androgen, R 1881, was as potent as TB in stimulating sexual behaviour and OB stimulated all aspects of copulatory behaviour but DHTB had no significant effect. The synthetic androgen, R 1881, is not metabolized by target cells and rapid metabolism could explain the failure of DHTB to stimulate sexual behaviour.
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U2 - 10.1677/joe.0.0870279
DO - 10.1677/joe.0.0870279
M3 - Article
C2 - 6968808
AN - SCOPUS:0019199139
SN - 0022-0795
VL - 87
SP - 279
EP - 283
JO - Journal of Endocrinology
JF - Journal of Endocrinology
IS - 2
ER -