Activation of sexual behaviour in castrated rats with the synthetic androgen 17β-hydroxy-17α-methyl-estra-4,9,11-triene-3-one (R 1881)

P. Sodersten, J. A. Gustafsson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Castrated sexually inactive rats were treated with the synthetic androgen 17β-hydroxy-17α-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R 1881), testosterone benzoate (TB), 5α-dihydrotestosterone benzoate (DHTB) or oestradiol benzoate (OB) and tested for sexual behaviour. The synthetic androgen, R 1881, was as potent as TB in stimulating sexual behaviour and OB stimulated all aspects of copulatory behaviour but DHTB had no significant effect. The synthetic androgen, R 1881, is not metabolized by target cells and rapid metabolism could explain the failure of DHTB to stimulate sexual behaviour.

Original languageEnglish (US)
Pages (from-to)279-283
Number of pages5
JournalJournal of Endocrinology
Volume87
Issue number2
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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