@article{75a048ac59124158b038c79779e35f4c,
title = "Activation of cre recombinase alone can induce complete tumor regression",
abstract = "The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediated Cre activation in vivo induced the regression of primary lymphomas in p532/2 mice. Our findings illustrate that Cre activation alone can induce the regression of established tumors.",
author = "Yulin Li and Choi, {Peter S.} and Casey, {Stephanie C.} and Felsher, {Dean W.}",
note = "Funding Information: The research was supported by grants from National Cancer Institute (R01CA170378, U54CA149145) and the Leukemia and Lymphoma Society Translational Research grant R6223-07 (DF). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2014 Li et al. Ci. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2014",
month = sep,
doi = "10.1371/journal.pone.0107589",
language = "English (US)",
volume = "9",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",
}