Activation of cre recombinase alone can induce complete tumor regression

Yulin Li, Peter S. Choi, Stephanie C. Casey, Dean W. Felsher

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediated Cre activation in vivo induced the regression of primary lymphomas in p532/2 mice. Our findings illustrate that Cre activation alone can induce the regression of established tumors.

Original languageEnglish (US)
Article numbere0107589
JournalPLoS ONE
Volume9
Issue number9
DOIs
StatePublished - Sep 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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