Actinomyces and Actinobacillus actinomycetemcomitans-Actinomyces-associated lymphadenopathy mimicking lymphoma

Mojgan Amrikachi, B. Krishnan, C. J. Finch, I. Shahab

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We present 2 unusual cases of long-standing, extensive reactive lymphadenopathy secondary to Actinomyces infection, 1 of which was also accompanied by Actinobacillus actinomycetemcomitans-Actinomyces complex infection. To our knowledge, histologic features of lymph node involvement by these organisms have not been previously reported in the literature. One patient had extensive cervical, posterior mediastinal, and abdominal lymphadenopathy. The second patient presented with a submandibular mass and cervical lymphadenopathy. Clinical features strongly suggested lymphoma. The histologic examination of the lymph nodes from both patients revealed reactive follicular hyperplasia, marked interfollicular and capsular fibrosis, and multiple interfollicular microabscesses. Characteristic Actinomyces colonies were identified at the center of the microabscesses in deep sections. Cultures were obtained from the lymph nodes of 1 patient, and were positive for A actinomycetemcomitans. Both patients had poor dental hygiene. Lymphadenopathy subsided with antibiotic therapy and appropriate dental care.

Original languageEnglish (US)
Pages (from-to)1502-1505
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number10
StatePublished - Nov 9 2000

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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