Actinic keratosis

Leonard Harry Goldberg, Diane Trieu, Anna Drosou

Research output: Chapter in Book/Report/Conference proceedingChapter


Actinic keratoses are sun-induced in situ epidermal tumors characterized by the proliferation of abnormal keratinocytes. Clinical lesions present as erythematous, rough, scaly, hyperkeratotic papules or plaques on sun exposed areas. However, a subclinical component may be present due to invasion of tumor cells down the hair follicle, sweat duct, or at the base of the epidermis without affecting keratinization and causing clinical change. Lesions with an increased risk of progression to invasive squamous cell carcinoma should be biopsied. The two main treatment approaches for actinic keratoses are field-directed and lesion-directed therapy. Cryotherapy is the most common form of treatment of actinic keratoses. Here, we present the technique, application, adverse events, efficacy, limitations, and compare cryotherapy versus other treatment modalities. Overall, cryotherapy coupled with field-directed therapy provides the best clinical outcome for the treatment of AKs.

Original languageEnglish (US)
Title of host publicationDermatological Cryosurgery and Cryotherapy
PublisherSpringer London
Number of pages9
ISBN (Electronic)9781447167655
ISBN (Print)9781447167648
StatePublished - Jan 1 2016


  • Actinic keratosis
  • Cryosurgery
  • Cryotherapy
  • Field directed therapy
  • Invasive squamous cell carcinoma
  • Lesion directed therapy
  • Proliferative actinic keratosis
  • Squamous cell carcinoma in situ

ASJC Scopus subject areas

  • Medicine(all)


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