TY - JOUR
T1 - Acquired Pelger-Huët Nuclear Anomaly With Tuberculosis
AU - Shenkenberg, Todd D.
AU - Rice, Lawrence
AU - Waddell, Caroline C.
PY - 1982/1
Y1 - 1982/1
N2 - Karel Pelger described an abnormality of granulocyte nuclear segmentation in the context of advanced tuberculosis, but G. Huet questioned this association. It is now recognized that the Pelger-Huet nuclear anomaly (PHNA) can be either hereditary or acquired with systemic diseases, commonly hematologic dysplasias. An association with tuberculosis has never been well verified. The man described in our study had cachexia, high fevers, severe hypoproliferative anemia, and acquired PHNA. At autopsy, an overwhelming tuberculosis was discovered in the absence of any other underlying disease. Acquired PHNA may serve as a diagnostic and prognostic indicator in tuberculosis.
AB - Karel Pelger described an abnormality of granulocyte nuclear segmentation in the context of advanced tuberculosis, but G. Huet questioned this association. It is now recognized that the Pelger-Huet nuclear anomaly (PHNA) can be either hereditary or acquired with systemic diseases, commonly hematologic dysplasias. An association with tuberculosis has never been well verified. The man described in our study had cachexia, high fevers, severe hypoproliferative anemia, and acquired PHNA. At autopsy, an overwhelming tuberculosis was discovered in the absence of any other underlying disease. Acquired PHNA may serve as a diagnostic and prognostic indicator in tuberculosis.
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U2 - 10.1001/archinte.1982.00340140155028
DO - 10.1001/archinte.1982.00340140155028
M3 - Article
C2 - 7053717
AN - SCOPUS:0020003133
VL - 142
SP - 153
EP - 154
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
SN - 0003-9926
IS - 1
ER -