Acquired hemophilia A after liver transplantation: A case report

Garrett M. Hisatake, Teng Wei Chen, John F. Renz, Douglas G. Farmer, R. Mark Ghobrial, Hasan Yersiz, Rafael G. Amado, Leonard Goldstein, Ronald W. Busuttil

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

It is well recognized that orthotopic liver transplantation rapidly corrects the coagulation disorder observed in patients with hemophilia A or B combined with end-stage liver disease; however, the transmission of hemophilia from a donor to a transplant recipient has not been reported previously. We describe a patient who developed acquired hemophilia A after liver transplantation due to the unknown presence of factor VIII inhibitor in the donor. The resulting coagulation disorder was unresponsive to standard factor replacement therapy, and was ultimately corrected with retransplantation. Hemophiliac donors should not be precluded from organ donation, though the presence of factor VIII inhibitor should be actively sought before organ procurement. High levels of factor VIII inhibitor represents an absolute contraindication to liver donation.

Original languageEnglish (US)
Pages (from-to)523-526
Number of pages4
JournalLiver Transplantation
Volume9
Issue number5
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

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