mporal bones with positively identifiable cholesteatoma were included in this study. 2. The morphology of the cholesteatoma matrix was identical to the epidermis of the tympanic membrane except for an increased population of Langerhans cells. 3. The advancing front of the cholesteatoma matrix showed papillary formation which appeared to be guided by the �contact guidance system� of Weiss. 4. The ground substances of the perimatrix in bone-resorbing cholesteatoma contained far fewer collagen fibers than that of the nonbone-resorbing cholesteatoma perimatrix. Abundant bone apatite crystalline-like substances were observed in the ground substances near the bone-resorbing area.
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