ACE inhibitor lacks acute effect on cognition or brain blood flow in alzheimer's disease

Myron F. Weiner; Frederick J. Bonte; Ron Tintner; Neville Ford; Doris Svetlik; Teresa Riall

doi:10.1002/ddr.430260410

ACE inhibitor lacks acute effect on cognition or brain blood flow in alzheimer's disease

Myron F. Weiner, Frederick J. Bonte, Ron Tintner, Neville Ford, Doris Svetlik, Teresa Riall

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The effects of the acute administration of the ACE inhibitor ceronapril were studied in 12 Alzheimer's disease (AD) patients and 2 age-matched controls. A 4-week open trial was performed with daily doses of 40-80 mg/day. Testing was performed at baseline and at 4 weeks using the Mini-mental State Exam and the cognitive portion of the Alzheimer's Disease Assessment Scale as cognitive measures, and regional cerebral blood flow (rCBF) as determined by Xe 133 single-photon emission computerized tomography as an indirect measure of brain metabolism. There was no effect on cognition and blood flow increased significantly only in the left temporal region. It was concluded that the acute administration of the ACE inhibitor ceronapril had no significant acute effect on cognitive function or rCBF in AD.

Original language	English (US)
Pages (from-to)	467-471
Number of pages	5
Journal	Drug Development Research
Volume	26
Issue number	4
DOIs	https://doi.org/10.1002/ddr.430260410
State	Published - 1992

Keywords

ceronapril
dementia
rCBF

ASJC Scopus subject areas

Organic Chemistry
Drug Discovery
Pharmacology

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10.1002/ddr.430260410

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abstract = "The effects of the acute administration of the ACE inhibitor ceronapril were studied in 12 Alzheimer's disease (AD) patients and 2 age-matched controls. A 4-week open trial was performed with daily doses of 40-80 mg/day. Testing was performed at baseline and at 4 weeks using the Mini-mental State Exam and the cognitive portion of the Alzheimer's Disease Assessment Scale as cognitive measures, and regional cerebral blood flow (rCBF) as determined by Xe 133 single-photon emission computerized tomography as an indirect measure of brain metabolism. There was no effect on cognition and blood flow increased significantly only in the left temporal region. It was concluded that the acute administration of the ACE inhibitor ceronapril had no significant acute effect on cognitive function or rCBF in AD.",

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AU - Weiner, Myron F.

AU - Bonte, Frederick J.

AU - Tintner, Ron

AU - Ford, Neville

AU - Svetlik, Doris

AU - Riall, Teresa

PY - 1992

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AB - The effects of the acute administration of the ACE inhibitor ceronapril were studied in 12 Alzheimer's disease (AD) patients and 2 age-matched controls. A 4-week open trial was performed with daily doses of 40-80 mg/day. Testing was performed at baseline and at 4 weeks using the Mini-mental State Exam and the cognitive portion of the Alzheimer's Disease Assessment Scale as cognitive measures, and regional cerebral blood flow (rCBF) as determined by Xe 133 single-photon emission computerized tomography as an indirect measure of brain metabolism. There was no effect on cognition and blood flow increased significantly only in the left temporal region. It was concluded that the acute administration of the ACE inhibitor ceronapril had no significant acute effect on cognitive function or rCBF in AD.

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ACE inhibitor lacks acute effect on cognition or brain blood flow in alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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