TY - JOUR
T1 - Accurate assessment of aootic stenosis severity by Doppler echocardiography independent of aortic jet velocity
AU - Zoghbi, William A.
AU - Galan, Augusto
AU - Quiñones, Miguel A.
N1 - Funding Information:
From the Section of Cardiology, Department of Medicine, Baylor College of Medicine and The Methodist Hospital Echocardiography Laboratory. Computational assistance was provided Grant RR-00350 from the Division Institutes of Health, Bethesda, Md. for publication Dec. 11, 1987; accepted May 15, 1988. Reprint requests: William A. Zoghbi, MD, Section of Cardiology, Baylor College of Medicine, 6535 Fannin, MS. F-1001, Houston, TX 77030.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1988/9
Y1 - 1988/9
N2 - The present investigation was designed to derive an accurate pulsed Doppler method of assessing aortic stenosis severity that does not rely on measurement of aortic jet velocity. Left ventricular ET and SV were determined from pulsed Doppler recordings of flow velocity at the aortic anulus in 44 mostly normotensive patients with aortic stenosis. Aortic valve area at catheterization ranged between 0.3 and 2.13 cm2. A predicted ET was derived from Doppler-determined SV with the use of a regression equation previously described by Harley et al. A significant inverse quadratic relation was observed between the ET difference (ΔET), defined as measured ET minus predicted ET, and valve area at catheterization (r = -0.87; valve area = 1.4 - 15 ΔET + 60 ΔET2; SEE = 0.23 cm2). An ET difference of ≥0.060 second was 88% sensitive, 89% specific, and 89% accurate for detecting critical aortic stenosis. Thus the ET difference, derived from measurements of SV and ET by pulsed Doppler, is a sensitive index for detection of critical aortic stenosis that is independent of determination of aortic jet velocity. This index should complement the Doppler evaluation of aortic stenosis, especially in cases where interrogation of the stenotic jet with continuous wave Doppler is inadequate.
AB - The present investigation was designed to derive an accurate pulsed Doppler method of assessing aortic stenosis severity that does not rely on measurement of aortic jet velocity. Left ventricular ET and SV were determined from pulsed Doppler recordings of flow velocity at the aortic anulus in 44 mostly normotensive patients with aortic stenosis. Aortic valve area at catheterization ranged between 0.3 and 2.13 cm2. A predicted ET was derived from Doppler-determined SV with the use of a regression equation previously described by Harley et al. A significant inverse quadratic relation was observed between the ET difference (ΔET), defined as measured ET minus predicted ET, and valve area at catheterization (r = -0.87; valve area = 1.4 - 15 ΔET + 60 ΔET2; SEE = 0.23 cm2). An ET difference of ≥0.060 second was 88% sensitive, 89% specific, and 89% accurate for detecting critical aortic stenosis. Thus the ET difference, derived from measurements of SV and ET by pulsed Doppler, is a sensitive index for detection of critical aortic stenosis that is independent of determination of aortic jet velocity. This index should complement the Doppler evaluation of aortic stenosis, especially in cases where interrogation of the stenotic jet with continuous wave Doppler is inadequate.
UR - http://www.scopus.com/inward/record.url?scp=0023705527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023705527&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(88)90348-1
DO - 10.1016/0002-8703(88)90348-1
M3 - Article
C2 - 3414498
AN - SCOPUS:0023705527
SN - 0002-8703
VL - 116
SP - 855
EP - 863
JO - American Heart Journal
JF - American Heart Journal
IS - 3
ER -