Absence of Retinoblastoma Protein Expression in Primary Non-Small Cell Lung Carcinomas

Hong Ji Xu, Shi Xue Hu, William F. Benedict, Philip T. Cagle, George E. Moore, Hong Ji Xu

Research output: Contribution to journalArticle

181 Scopus citations

Abstract

Retinoblastoma (RB) protein expression was examined in paraffin and frozen tissue sections of 36 primary non-small cell lung carcinomas (NSCLC) using immunohistochemistry with confirmation by direct Western blotting. A normal RB protein staining pattern was present in 24 and absent in 10 NSCLC. Two additional RB positive primary tumors have major foci in which all tumor cells showed no RB protein staining. Significantly more high-stage (stages III and IV) NSCLC had altered RB protein expression than those with low-stage (stages I and II) tumors (P < 0.05). The results suggest that absence of the RB expression may be associated with the initiation and/or progression of many NSCLC. This is the first report of successful RB staining in paraffin sections.

Original languageEnglish (US)
Pages (from-to)2735-2739
Number of pages5
JournalCancer research
Volume51
Issue number10
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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