This study demonstrates a possible disadvantage of crossing ABO barriers in liver transplantations. In adult recipients, those who received ABO-compatible livers had lower graft survivals if the ABO antigen were not identical. This could be due to the fact that transplanted liver might produce hemoagglutinins against the mismatched recipient's ABO antigens that eventually would damage the transplanted liver. Another possible reason why these pediatric livers provided a higher graft survival rate could be that the pediatric liver cells bear fewer ABO antigens compared to the adult liver cells. Yet before extended studies are completed, ABO-identical grafts should be recommended in adult liver transplantation except in emergency situations.
|Original language||English (US)|
|Number of pages||2|
|Issue number||1 SUPPL. 1|
|State||Published - 1988|
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