Abnormalities of immunoregulation in juvenile rheumatoid arthritis

K. S. Barron, C. L. Decunto, J. F. Montalvo, F. M. Orson, Dorothy E. Lewis

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Immunoregulatory imbalances are thought to be involved in the pathogenesis of juvenile rheumatoid arthritis (JRA). We have found that a subset of patients with JRA demonstrate a marked expansion of B cells without an alteration in B cell subset distribution. However, there was actually decreased in vitro immunoglobulin production in response to stimulation with either pokeweed mitogen or hydrocortisone. These B cell abnormalities were found to correlate with a marked increase in the percentage of CD4+CD45R+ T cells, a T cell subset thought to be responsible for inducing suppression. In addition, there was a significant decrease in the percentage of CD4+CD29+ T cells, a T cell subset thought to be responsible for inducing B cell immunoglobulin production. Our results suggest that the B cell abnormalities seen in JRA may be related to defects in T cell immunoregulation.

Original languageEnglish (US)
Pages (from-to)940-948
Number of pages9
JournalJournal of Rheumatology
Volume16
Issue number7
StatePublished - 1989

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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