Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia

Teresa G. Hayes, Xiao Lin Tan, Annemarie B. Moseley, Marilyn M. Huston, David P. Huston

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In B-cell chronic lymphocytic leukemia, neoplastic B-lymphocytes are arrested in development. Since interleukins are essential for B-cell differentiation, we examined whether B-CLL cells were capable of responding normally to interleukins. Purified B-lymphocytes from B-CLL patients and controls were compared for their ability to proliferate and differentiate after stimulation with MCAT or SAC plus rhIL-2 or rhIL-5. When rhIL-5 was added to MCAT-stimulated cells, 8 of 10 controls showed a substantial increase in IgM production, compared with only 1 of 10 B-CLL patients. Lack of IL-5 responsiveness could provide insight into the arrested B-lymphocyte development of some B-CLL patients.

Original languageEnglish (US)
Pages (from-to)777-783
Number of pages7
JournalLeukemia Research
Volume17
Issue number9
DOIs
StatePublished - Sep 1993

Keywords

  • B-CLL
  • B-lymphocyte differentiation
  • IL-2
  • IL-5
  • MCAT
  • SAC

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Cancer Research

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