A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging

Hong Wei An; Li Li Li; Yi Wang; Ziqi Wang; Dayong Hou; Yao Xin Lin; Sheng Lin Qiao; Man Di Wang; Chao Yang; Yong Cong; Yang Ma; Xiao Xiao Zhao; Qian Cai; Wen Ting Chen; Chu Qi Lu; Wanhai Xu; Hao Wang; Yuliang Zhao

doi:10.1038/s41467-019-12848-5

A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging

Hong Wei An, Li Li Li, Yi Wang, Ziqi Wang, Dayong Hou, Yao Xin Lin, Sheng Lin Qiao, Man Di Wang, Chao Yang, Yong Cong, Yang Ma, Xiao Xiao Zhao, Qian Cai, Wen Ting Chen, Chu Qi Lu, Wanhai Xu, Hao Wang, Yuliang Zhao

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes and therapeutics. We show in different mouse models that the TCASS system accumulates in solid tumours. The molecules show enhanced accumulation in tumour regions via the effect of recognition induced self-assembly. Analysis of the molecular penetration in tumour tissue shows that in vivo self-assembly increases the penetration capability compared to typical soft or hard nanomaterials. Importantly, the in vivo self-assembled molecules exhibit a comparable clearance pathway to that of small molecules, which are excreted from organs of the reticuloendothelial system (liver and kidney), while are relatively slowly eliminated from tumour tissues. Finally, this system, combined with the NIR probe, shows high specificity and sensitivity for detecting bladder cancer in isolated intact patient bladders.

Original language	English (US)
Article number	4861
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-12848-5
State	Published - Dec 1 2019

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

Access to Document

10.1038/s41467-019-12848-5

Cite this

An, H. W., Li, L. L., Wang, Y., Wang, Z., Hou, D., Lin, Y. X., Qiao, S. L., Wang, M. D., Yang, C., Cong, Y., Ma, Y., Zhao, X. X., Cai, Q., Chen, W. T., Lu, C. Q., Xu, W., Wang, H., & Zhao, Y. (2019). A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging. Nature Communications, 10(1), Article 4861. https://doi.org/10.1038/s41467-019-12848-5

@article{3ae80366186844879210b45c2402d70a,

title = "A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging",

abstract = "Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes and therapeutics. We show in different mouse models that the TCASS system accumulates in solid tumours. The molecules show enhanced accumulation in tumour regions via the effect of recognition induced self-assembly. Analysis of the molecular penetration in tumour tissue shows that in vivo self-assembly increases the penetration capability compared to typical soft or hard nanomaterials. Importantly, the in vivo self-assembled molecules exhibit a comparable clearance pathway to that of small molecules, which are excreted from organs of the reticuloendothelial system (liver and kidney), while are relatively slowly eliminated from tumour tissues. Finally, this system, combined with the NIR probe, shows high specificity and sensitivity for detecting bladder cancer in isolated intact patient bladders.",

author = "An, {Hong Wei} and Li, {Li Li} and Yi Wang and Ziqi Wang and Dayong Hou and Lin, {Yao Xin} and Qiao, {Sheng Lin} and Wang, {Man Di} and Chao Yang and Yong Cong and Yang Ma and Zhao, {Xiao Xiao} and Qian Cai and Chen, {Wen Ting} and Lu, {Chu Qi} and Wanhai Xu and Hao Wang and Yuliang Zhao",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",

year = "2019",

month = dec,

day = "1",

doi = "10.1038/s41467-019-12848-5",

language = "English (US)",

volume = "10",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging

AU - An, Hong Wei

AU - Li, Li Li

AU - Wang, Yi

AU - Wang, Ziqi

AU - Hou, Dayong

AU - Lin, Yao Xin

AU - Qiao, Sheng Lin

AU - Wang, Man Di

AU - Yang, Chao

AU - Cong, Yong

AU - Ma, Yang

AU - Zhao, Xiao Xiao

AU - Cai, Qian

AU - Chen, Wen Ting

AU - Lu, Chu Qi

AU - Xu, Wanhai

AU - Wang, Hao

AU - Zhao, Yuliang

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes and therapeutics. We show in different mouse models that the TCASS system accumulates in solid tumours. The molecules show enhanced accumulation in tumour regions via the effect of recognition induced self-assembly. Analysis of the molecular penetration in tumour tissue shows that in vivo self-assembly increases the penetration capability compared to typical soft or hard nanomaterials. Importantly, the in vivo self-assembled molecules exhibit a comparable clearance pathway to that of small molecules, which are excreted from organs of the reticuloendothelial system (liver and kidney), while are relatively slowly eliminated from tumour tissues. Finally, this system, combined with the NIR probe, shows high specificity and sensitivity for detecting bladder cancer in isolated intact patient bladders.

AB - Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes and therapeutics. We show in different mouse models that the TCASS system accumulates in solid tumours. The molecules show enhanced accumulation in tumour regions via the effect of recognition induced self-assembly. Analysis of the molecular penetration in tumour tissue shows that in vivo self-assembly increases the penetration capability compared to typical soft or hard nanomaterials. Importantly, the in vivo self-assembled molecules exhibit a comparable clearance pathway to that of small molecules, which are excreted from organs of the reticuloendothelial system (liver and kidney), while are relatively slowly eliminated from tumour tissues. Finally, this system, combined with the NIR probe, shows high specificity and sensitivity for detecting bladder cancer in isolated intact patient bladders.

UR - http://www.scopus.com/inward/record.url?scp=85074083447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074083447&partnerID=8YFLogxK

U2 - 10.1038/s41467-019-12848-5

DO - 10.1038/s41467-019-12848-5

M3 - Article

C2 - 31649241

AN - SCOPUS:85074083447

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 4861

ER -

A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this