A sustained hypothalamic-pituitary-Adrenal axis response to acute psychosocial stress in irritable bowel syndrome

P. J. Kennedy, J. F. Cryan, E. M.M. Quigley, T. G. Dinan, G. Clarke

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


Background Despite stress being considered a key factor in the pathophysiology of the functional gastrointestinal (GI) disorder irritable bowel syndrome (IBS), there is a paucity of information regarding the ability of IBS patients to respond to acute experimental stress. Insights into the stress response in IBS could open the way to novel therapeutic interventions. To this end, we assessed the response of a range of physiological and psychological parameters to the Trier Social Stress Test (TSST) in IBS. Method Thirteen female patients with IBS and 15 healthy female age-matched control participants underwent a single exposure to the TSST. Salivary cortisol, salivary C-reactive protein (CRP), skin conductance level (SCL), GI symptoms, mood and self-reported stress were measured pre-And post-exposure to the TSST. Results The hypothalamic-pituitary-Adrenal (HPA) axis response to the TSST was sustained in IBS, as shown by a greater total cortisol output throughout (p=0.035) and higher cortisol levels measured by an area under the curve with respect to ground (AUCG) analysis (p=0.044). In IBS patients, GI symptoms increased significantly during the recovery period following exposure to the TSST (p=0.045). Salivary CRP and SCL activity showed significant changes in relation to stress but with no differential effect between experimental groups. Conclusions Patients with IBS exhibit sustained HPA axis activity, and an increase in problematic GI symptoms in response to acute experimental psychosocial stress. These data pave the way for future interventional studies aimed at identifying novel therapeutic approaches to modulate the HPA axis and GI symptom response to acute psychosocial stress in IBS.

Original languageEnglish (US)
Pages (from-to)3123-3134
Number of pages12
JournalPsychological Medicine
Issue number14
StatePublished - Oct 2014


  • Gastrointestinal symptoms
  • HPA axis
  • Trier Social Stress Test
  • irritable bowel syndrome
  • stress

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


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