A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladder: Epidemiology, prognostic variables, and treatment trends

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62 Scopus citations

Abstract

Background: Small cell carcinoma of the urinary bladder (SCCB) is difficult to characterize and study because of its rarity. For the current study, a large population-based database was used to address ill-defined clinical parameters for this disease. METHODS: The authors analyzed the incidence, sociodemographics, prognostic variables, and treatment trends of this cancer in the Surveillance, Epidemiology, and End Results (SEER) limited database (1991-2005). The SEER-Medicare database (1991-2005) was used to estimate chemotherapy use. RESULTS: There were 642 patients in the SEER limited dataset. From 1991 to 2005, the incidence of SCCB increased significantly from 0.05 to 0.14 cases per 100,000 population (P <.01; approximately 500 new cases of SCCB per year, representing 0.7% of all bladder malignancies). The median overall survival was 11 months. Elderly Caucasian men were the most commonly affected (ratio of Caucasians to non-Caucasians, 10:1; ratio of men to women, 3:1; median age, 73 years). Age, race, marital status, and TNM staging were identified as independent prognostic variables (P <.05). Patients who had stage IV disease without distant metastasis (ie, positive lymph node status) had overall and cancer-specific survival rates similar to those of patients who had stage I through III disease, but they had significantly better survival compared with patients who had distant metastasis (P <.0001). Transurethral resection of the bladder tumor became the most common surgical treatment (P <.0001), representing 55% of patients from 2001 to 2005. The receipt of radiation and chemotherapy did not change significantly during the study period. CONCLUSIONS: These comprehensive data delineated the patient population for this rare disease, described several independent prognostic variables, and demonstrated clear treatment trends for this disease. The results suggest that a simpler staging system (ie, limited stage vs extensive stage) may be appropriate for patients with SCCB.

Original languageEnglish (US)
Pages (from-to)5325-5333
Number of pages9
JournalCancer
Volume117
Issue number23
DOIs
StatePublished - Dec 1 2011

Keywords

  • bladder
  • epidemiology
  • genitourinary
  • small cell
  • Surveillance, Epidemiology, and End Results

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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