Abstract

The response to allografting involves adaptive and innate immune mechanisms. In the adaptive system, activated T cells differentiate to cytotoxic effectors that attack the graft and trigger B cells to differentiation to plasma cells that produce anti-HLA antibodies. The innate immune system recognizes antigens in a non-specific manner and recruits immune cells to the graft through the productions of chemotactic factors, and activation of cytokines and the complement cascade. In the kidney the tubules and the endothelium are the targets of the rejection response. Immune suppression is effective in modulating the adaptive immune system effect on graft histology.

Original languageEnglish (US)
Pages (from-to)1293-1307
Number of pages15
JournalSurgical Clinics of North America
Volume93
Issue number6
DOIs
StatePublished - Dec 1 2013

Keywords

  • Adaptive immune responses
  • Biopsy
  • Graft rejection
  • Immune suppression

ASJC Scopus subject areas

  • Surgery

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