A support for the luteal phase: Supplementation with Vitamin D, inositol and melatonin

Lidia Di Cerbo, Conisha Holloman, Monica Longo

Research output: Chapter in Book/Report/Conference proceedingChapter


The synthesis and secretion of progesterone (P4) by the corpus luteum in the luteal phase are of crucial importance in determining the implantation of the blastocyst and the maintenance of pregnancy in the early first trimester. Luteal phase deficiency (LPD) is associated with many fertility disorders and higher pregnancy losses. Although several studies, in human and animal models, have been performed to understand luteal biology, there is still a lack of knowledge on luteal phase defects and controversies regarding the diagnosis and potential treatment of luteal inadequacy. Vitamin and non-vitamin supplements such as vitamin D, inositol and melatonin are newer innovative treatments that could provide support for the luteal phase defects.

Original languageEnglish (US)
Title of host publicationVitamin D as Progesterone-Like Hormone
Subtitle of host publicationNovel Applications in Obstetrics and Gynecology
PublisherNova Science Publishers, Inc.
Number of pages26
ISBN (Electronic)9781536175172
ISBN (Print)9781536175165
StatePublished - May 1 2020


  • Inositol
  • Luteal phase
  • Melatonin
  • Supplementation
  • Vitamin D

ASJC Scopus subject areas

  • Medicine(all)


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