A study of chorea after tetrabenazine withdrawal in patients with Huntington disease

Samuel Frank; William G. Ondo; Stanley Fahn; Christine Hunter; David Oakes; Sandra Plumb; Frederick Marshall; Ira Shoulson; Shirley Eberly; Francis Walker; Stewart Factor; Vicki Hunt; Aileen Shinaman; Joseph Jankovic

doi:10.1097/WNF.0b013e3180ca77ea

A study of chorea after tetrabenazine withdrawal in patients with Huntington disease

Samuel Frank, William G. Ondo, Stanley Fahn, Christine Hunter, David Oakes, Sandra Plumb, Frederick Marshall, Ira Shoulson, Shirley Eberly, Francis Walker, Stewart Factor, Vicki Hunt, Aileen Shinaman, Joseph Jankovic

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

OBJECTIVE: To assess tetrabenazine (TBZ) efficacy by evaluating the change in Huntington disease-associated chorea resulting from TBZ treatment withdrawal. METHODS: Thirty patients treated in the long term were randomized to 1 of 3 groups assigned to withdraw from TBZ in a double-blind, staggered fashion during a 5-day period. RESULTS: The chorea scores of subjects withdrawn from TBZ treatment increased by 5.3 units from days 1 to 3, whereas the scores of the group with partial or no withdrawal of TBZ treatment increased by 3.0 units (P = 0.0773). A post hoc analysis of the linear trend was positive for reemergent chorea (P = 0.0486). No serious adverse events were reported after abrupt withdrawal of TBZ treatment. CONCLUSIONS: The trend for reemergence of chorea in patients with Huntington disease who were withdrawn from TBZ treatment is consistent with the findings from previous studies, thus showing the effectiveness of TBZ in reducing chorea.

Original language	English (US)
Pages (from-to)	127-133
Number of pages	7
Journal	Clinical Neuropharmacology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1097/WNF.0b013e3180ca77ea
State	Published - May 2008

Keywords

Chorea
Huntington disease
Tetrabenazine

ASJC Scopus subject areas

Pharmacology
Clinical Neurology
Pharmacology (medical)

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abstract = "OBJECTIVE: To assess tetrabenazine (TBZ) efficacy by evaluating the change in Huntington disease-associated chorea resulting from TBZ treatment withdrawal. METHODS: Thirty patients treated in the long term were randomized to 1 of 3 groups assigned to withdraw from TBZ in a double-blind, staggered fashion during a 5-day period. RESULTS: The chorea scores of subjects withdrawn from TBZ treatment increased by 5.3 units from days 1 to 3, whereas the scores of the group with partial or no withdrawal of TBZ treatment increased by 3.0 units (P = 0.0773). A post hoc analysis of the linear trend was positive for reemergent chorea (P = 0.0486). No serious adverse events were reported after abrupt withdrawal of TBZ treatment. CONCLUSIONS: The trend for reemergence of chorea in patients with Huntington disease who were withdrawn from TBZ treatment is consistent with the findings from previous studies, thus showing the effectiveness of TBZ in reducing chorea.",

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AU - Frank, Samuel

AU - Ondo, William G.

AU - Fahn, Stanley

AU - Hunter, Christine

AU - Oakes, David

AU - Plumb, Sandra

AU - Marshall, Frederick

AU - Shoulson, Ira

AU - Eberly, Shirley

AU - Walker, Francis

AU - Factor, Stewart

AU - Hunt, Vicki

AU - Shinaman, Aileen

AU - Jankovic, Joseph

PY - 2008/5

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N2 - OBJECTIVE: To assess tetrabenazine (TBZ) efficacy by evaluating the change in Huntington disease-associated chorea resulting from TBZ treatment withdrawal. METHODS: Thirty patients treated in the long term were randomized to 1 of 3 groups assigned to withdraw from TBZ in a double-blind, staggered fashion during a 5-day period. RESULTS: The chorea scores of subjects withdrawn from TBZ treatment increased by 5.3 units from days 1 to 3, whereas the scores of the group with partial or no withdrawal of TBZ treatment increased by 3.0 units (P = 0.0773). A post hoc analysis of the linear trend was positive for reemergent chorea (P = 0.0486). No serious adverse events were reported after abrupt withdrawal of TBZ treatment. CONCLUSIONS: The trend for reemergence of chorea in patients with Huntington disease who were withdrawn from TBZ treatment is consistent with the findings from previous studies, thus showing the effectiveness of TBZ in reducing chorea.

AB - OBJECTIVE: To assess tetrabenazine (TBZ) efficacy by evaluating the change in Huntington disease-associated chorea resulting from TBZ treatment withdrawal. METHODS: Thirty patients treated in the long term were randomized to 1 of 3 groups assigned to withdraw from TBZ in a double-blind, staggered fashion during a 5-day period. RESULTS: The chorea scores of subjects withdrawn from TBZ treatment increased by 5.3 units from days 1 to 3, whereas the scores of the group with partial or no withdrawal of TBZ treatment increased by 3.0 units (P = 0.0773). A post hoc analysis of the linear trend was positive for reemergent chorea (P = 0.0486). No serious adverse events were reported after abrupt withdrawal of TBZ treatment. CONCLUSIONS: The trend for reemergence of chorea in patients with Huntington disease who were withdrawn from TBZ treatment is consistent with the findings from previous studies, thus showing the effectiveness of TBZ in reducing chorea.

KW - Chorea

KW - Huntington disease

KW - Tetrabenazine

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A study of chorea after tetrabenazine withdrawal in patients with Huntington disease

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