TY - JOUR
T1 - A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy
AU - Ji, Chendong
AU - Gao, Qin
AU - Dong, Xinghua
AU - Yin, Wenyan
AU - Gu, Zhanjun
AU - Gan, Zhihua
AU - Zhao, Yuliang
AU - Yin, Meizhen
PY - 2018/8/27
Y1 - 2018/8/27
N2 - Fluorescent dyes with multi-functionality are of great interest for photo-based cancer theranostics. However, their low singlet oxygen quantum yield impedes their potential applications for photodynamic therapy (PDT). Now, a molecular self-assembly strategy is presented for a nanodrug with a remarkably enhanced photodynamic effect based on a dye-chemodrug conjugate. The self-assembled nanodrug possesses an increased intersystem crossing rate owing to the aggregation of dye, leading to a distinct singlet oxygen quantum yield (Φ(1O2)). Subsequently, upon red light irradiation, the generated singlet oxygen reduces the size of the nanodrug from 90 to 10 nm, which facilitates deep tumor penetration of the nanodrug and release of chemodrug. The nanodrug achieved in situ tumor imaging and potent tumor inhibition by deep chemo-PDT. Our work verifies a facile and effective self-assembly strategy to construct nanodrugs with enhanced performance for cancer theranostics.
AB - Fluorescent dyes with multi-functionality are of great interest for photo-based cancer theranostics. However, their low singlet oxygen quantum yield impedes their potential applications for photodynamic therapy (PDT). Now, a molecular self-assembly strategy is presented for a nanodrug with a remarkably enhanced photodynamic effect based on a dye-chemodrug conjugate. The self-assembled nanodrug possesses an increased intersystem crossing rate owing to the aggregation of dye, leading to a distinct singlet oxygen quantum yield (Φ(1O2)). Subsequently, upon red light irradiation, the generated singlet oxygen reduces the size of the nanodrug from 90 to 10 nm, which facilitates deep tumor penetration of the nanodrug and release of chemodrug. The nanodrug achieved in situ tumor imaging and potent tumor inhibition by deep chemo-PDT. Our work verifies a facile and effective self-assembly strategy to construct nanodrugs with enhanced performance for cancer theranostics.
KW - aggregation-enhanced photodynamic effect
KW - multifunctionality
KW - nanodrugs
KW - pentamethine indocyanine
KW - size reducibility
UR - http://www.scopus.com/inward/record.url?scp=85051857932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051857932&partnerID=8YFLogxK
U2 - 10.1002/anie.201807602
DO - 10.1002/anie.201807602
M3 - Article
C2 - 30003656
AN - SCOPUS:85051857932
SN - 1433-7851
VL - 57
SP - 11384
EP - 11388
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 35
ER -