A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy

Chendong Ji, Qin Gao, Xinghua Dong, Wenyan Yin, Zhanjun Gu, Zhihua Gan, Yuliang Zhao, Meizhen Yin

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Fluorescent dyes with multi-functionality are of great interest for photo-based cancer theranostics. However, their low singlet oxygen quantum yield impedes their potential applications for photodynamic therapy (PDT). Now, a molecular self-assembly strategy is presented for a nanodrug with a remarkably enhanced photodynamic effect based on a dye-chemodrug conjugate. The self-assembled nanodrug possesses an increased intersystem crossing rate owing to the aggregation of dye, leading to a distinct singlet oxygen quantum yield (Φ(1O2)). Subsequently, upon red light irradiation, the generated singlet oxygen reduces the size of the nanodrug from 90 to 10 nm, which facilitates deep tumor penetration of the nanodrug and release of chemodrug. The nanodrug achieved in situ tumor imaging and potent tumor inhibition by deep chemo-PDT. Our work verifies a facile and effective self-assembly strategy to construct nanodrugs with enhanced performance for cancer theranostics.

Original languageEnglish (US)
Pages (from-to)11384-11388
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number35
DOIs
StatePublished - Aug 27 2018

Keywords

  • aggregation-enhanced photodynamic effect
  • multifunctionality
  • nanodrugs
  • pentamethine indocyanine
  • size reducibility

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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