A single institution experience with pediatric nasopharyngeal carcinoma: High incidence of toxicity associated with platinum-based chemotherapy plus IMRT

Chrystal U. Louis; Arnold C. Paulino; Stephen Gottschalk; Allison A. Bertuch; Murali Chintagumpala; Helen E. Heslop; Heidi V. Russell

doi:10.1097/MPH.0b013e3180959af4

A single institution experience with pediatric nasopharyngeal carcinoma: High incidence of toxicity associated with platinum-based chemotherapy plus IMRT

Chrystal U. Louis, Arnold C. Paulino, Stephen Gottschalk, Allison A. Bertuch, Murali Chintagumpala, Helen E. Heslop, Heidi V. Russell

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

BACKGROUND: Chemotherapy and intensity-modulated radiotherapy (IMRT) have decreased treatment-related complications in adult patients with nasopharyngeal carcinoma (NPC). Our aim was to evaluate the toxicity profile of IMRT plus chemotherapy in pediatric NPC patients. OBSERVATIONS: Five patients were treated with chemotherapy and IMRT. All patients experienced grade 3-4 acute toxicities. With a median follow-up of 6.3 years, all patients experienced ≥3 long-term toxicities. The most common toxicities were hypothyroidism, xerostomia, hearing loss, and dental disease. CONCLUSIONS: We did not observe a significant decrease in long-term toxicities with IMRT plus chemotherapy in our small cohort of pediatric NPC patients.

Original language	English (US)
Pages (from-to)	500-505
Number of pages	6
Journal	Journal of pediatric hematology/oncology
Volume	29
Issue number	7
DOIs	https://doi.org/10.1097/MPH.0b013e3180959af4
State	Published - Jul 2007

Keywords

IMRT
Long-term effects
Nasopharyngeal carcinoma
Pediatrics

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Oncology
Hematology

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10.1097/MPH.0b013e3180959af4

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Louis, C. U., Paulino, A. C., Gottschalk, S., Bertuch, A. A., Chintagumpala, M., Heslop, H. E., & Russell, H. V. (2007). A single institution experience with pediatric nasopharyngeal carcinoma: High incidence of toxicity associated with platinum-based chemotherapy plus IMRT. Journal of pediatric hematology/oncology, 29(7), 500-505. https://doi.org/10.1097/MPH.0b013e3180959af4

A single institution experience with pediatric nasopharyngeal carcinoma : High incidence of toxicity associated with platinum-based chemotherapy plus IMRT. / Louis, Chrystal U.; Paulino, Arnold C.; Gottschalk, Stephen et al.

In: Journal of pediatric hematology/oncology, Vol. 29, No. 7, 07.2007, p. 500-505.

Research output: Contribution to journal › Article › peer-review

Louis, CU, Paulino, AC, Gottschalk, S, Bertuch, AA, Chintagumpala, M, Heslop, HE & Russell, HV 2007, 'A single institution experience with pediatric nasopharyngeal carcinoma: High incidence of toxicity associated with platinum-based chemotherapy plus IMRT', Journal of pediatric hematology/oncology, vol. 29, no. 7, pp. 500-505. https://doi.org/10.1097/MPH.0b013e3180959af4

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abstract = "BACKGROUND: Chemotherapy and intensity-modulated radiotherapy (IMRT) have decreased treatment-related complications in adult patients with nasopharyngeal carcinoma (NPC). Our aim was to evaluate the toxicity profile of IMRT plus chemotherapy in pediatric NPC patients. OBSERVATIONS: Five patients were treated with chemotherapy and IMRT. All patients experienced grade 3-4 acute toxicities. With a median follow-up of 6.3 years, all patients experienced ≥3 long-term toxicities. The most common toxicities were hypothyroidism, xerostomia, hearing loss, and dental disease. CONCLUSIONS: We did not observe a significant decrease in long-term toxicities with IMRT plus chemotherapy in our small cohort of pediatric NPC patients.",

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AB - BACKGROUND: Chemotherapy and intensity-modulated radiotherapy (IMRT) have decreased treatment-related complications in adult patients with nasopharyngeal carcinoma (NPC). Our aim was to evaluate the toxicity profile of IMRT plus chemotherapy in pediatric NPC patients. OBSERVATIONS: Five patients were treated with chemotherapy and IMRT. All patients experienced grade 3-4 acute toxicities. With a median follow-up of 6.3 years, all patients experienced ≥3 long-term toxicities. The most common toxicities were hypothyroidism, xerostomia, hearing loss, and dental disease. CONCLUSIONS: We did not observe a significant decrease in long-term toxicities with IMRT plus chemotherapy in our small cohort of pediatric NPC patients.

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A single institution experience with pediatric nasopharyngeal carcinoma: High incidence of toxicity associated with platinum-based chemotherapy plus IMRT

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