A single institution experience with pediatric nasopharyngeal carcinoma: High incidence of toxicity associated with platinum-based chemotherapy plus IMRT

Chrystal U. Louis, Arnold C. Paulino, Stephen Gottschalk, Allison A. Bertuch, Murali Chintagumpala, Helen E. Heslop, Heidi V. Russell

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

BACKGROUND: Chemotherapy and intensity-modulated radiotherapy (IMRT) have decreased treatment-related complications in adult patients with nasopharyngeal carcinoma (NPC). Our aim was to evaluate the toxicity profile of IMRT plus chemotherapy in pediatric NPC patients. OBSERVATIONS: Five patients were treated with chemotherapy and IMRT. All patients experienced grade 3-4 acute toxicities. With a median follow-up of 6.3 years, all patients experienced ≥3 long-term toxicities. The most common toxicities were hypothyroidism, xerostomia, hearing loss, and dental disease. CONCLUSIONS: We did not observe a significant decrease in long-term toxicities with IMRT plus chemotherapy in our small cohort of pediatric NPC patients.

Original languageEnglish (US)
Pages (from-to)500-505
Number of pages6
JournalJournal of pediatric hematology/oncology
Volume29
Issue number7
DOIs
StatePublished - Jul 2007

Keywords

  • IMRT
  • Long-term effects
  • Nasopharyngeal carcinoma
  • Pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

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