A simultaneous dual-isotope acquisition and imaging fusion protocol in nuclear medicine: 111In-Octreotide SPECT and 99mTC-HMDP bone SPECT

P. Zanotti-Fregonara, I. Keller, J. Y. Devaux, A. Massaro, Domenico Rubello, E. Hindé

Research output: Contribution to journalArticle

Abstract

In the present preliminary study, we developed a protocol for the acquisition and fusion of dual isotope tomographic (SPECT) images (111In-Octreotide SPECT and 99mTc-HMDP SPECT). This procedure was performed in ten consecutive patients, and the first results were encouraging: it proved to be a simple and accurate method to improve the anatomic localization of 111In-Octreotide SPECT positive foci for the staging and follow-up of tumours expressing somatostatin receptors (Octreotide is an analog of somatostatin), particularly in discriminating bone metastases from soft tissue metastases located near to bone itself.

Original languageEnglish (US)
Pages (from-to)133-135
Number of pages3
JournalMinerva Biotecnologica
Volume20
Issue number3
StatePublished - Sep 1 2008

Keywords

  • Bone neoplasms, secondary
  • Emission-computed, single-photon
  • In-octreotide
  • Isotope
  • Neoplasm metastasis
  • Tomography

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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