A role for K(ATP)/+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla

Eugene V. Golanov, Donald J. Reis

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Reticulospinal sympathoexcitatory neurons of rostral ventrolateral medulla (RVL) are selectively excited by hypoxia to elevate arterial pressure (AP) and cerebral blood flow (rCBF), that are elements of the oxygen- conserving (diving) reflex. We investigated whether K(ATP)/+-channels participate in this. Tolbutamide and glibenclamide, K(ATP)/+-channel blockers, microinjected into RVL in anesthetized rats, dose-dependently and site-specifically elevated AP and rCBF and potentiated responses to hypoxemia. K(ATP)/+-channels may mediate hypoxic excitation of oxygen- sensing RVL neurons.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalBrain Research
Volume827
Issue number1-2
DOIs
StatePublished - May 8 1999

Keywords

  • Arterial pressure
  • ATP-sensitive potassium channel
  • Cerebral blood flow
  • Hypoxia
  • Oxygen
  • Rostral ventrolateral medulla

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

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