A role for decorin in cutaneous wound healing and angiogenesis

Hannu Järveläinen; Pauli Puolakkainen; Sari Pakkanen; Eric L. Brown; Magnus Höök; Renato V. Iozzo; E. Helene Sage; Thomas N. Wight

doi:10.1111/j.1743-6109.2006.00150.x

A role for decorin in cutaneous wound healing and angiogenesis

Hannu Järveläinen, Pauli Puolakkainen, Sari Pakkanen, Eric L. Brown, Magnus Höök, Renato V. Iozzo, E. Helene Sage, Thomas N. Wight

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

Decorin is known to influence tissue tensile strength and cellular phenotype. Therefore, decorin is likely to have an impact on tissue repair, including cutaneous wound healing. In this study, cutaneous healing of both excisional and incisional full-thickness dermal wounds was studied in decorin-deficient (Dcn^-/-) animals. A statistically significant delay in excisional wound healing in the Dcn^-/- mice occurred at 4 and 10 days postwounding and, in incisional wounds at 4, 10, and 18 days when compared with wild-type (Dcn^-/-) controls. Fibrovascular invasion into polyvinylalcohol sponges was significantly increased by day 18 in Dcn ^-/- mice relative to Dcn^+/+ mice. The 18-day sponge implants in the Dcn^-/- mice showed a marked accumulation of biglycan when compared with the corresponding implants in Dcn^+/+ mice. Thus, regulated production of decorin may serve as an excellent therapeutic approach for modifying impaired wound healing and harmful foreign body reactions.

Original language	English (US)
Pages (from-to)	443-452
Number of pages	10
Journal	Wound Repair and Regeneration
Volume	14
Issue number	4
DOIs	https://doi.org/10.1111/j.1743-6109.2006.00150.x
State	Published - Jul 2006

ASJC Scopus subject areas

Surgery
Dermatology

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title = "A role for decorin in cutaneous wound healing and angiogenesis",

abstract = "Decorin is known to influence tissue tensile strength and cellular phenotype. Therefore, decorin is likely to have an impact on tissue repair, including cutaneous wound healing. In this study, cutaneous healing of both excisional and incisional full-thickness dermal wounds was studied in decorin-deficient (Dcn-/-) animals. A statistically significant delay in excisional wound healing in the Dcn-/- mice occurred at 4 and 10 days postwounding and, in incisional wounds at 4, 10, and 18 days when compared with wild-type (Dcn-/-) controls. Fibrovascular invasion into polyvinylalcohol sponges was significantly increased by day 18 in Dcn -/- mice relative to Dcn+/+ mice. The 18-day sponge implants in the Dcn-/- mice showed a marked accumulation of biglycan when compared with the corresponding implants in Dcn+/+ mice. Thus, regulated production of decorin may serve as an excellent therapeutic approach for modifying impaired wound healing and harmful foreign body reactions.",

author = "Hannu J{\"a}rvel{\"a}inen and Pauli Puolakkainen and Sari Pakkanen and Brown, {Eric L.} and Magnus H{\"o}{\"o}k and Iozzo, {Renato V.} and Sage, {E. Helene} and Wight, {Thomas N.}",

year = "2006",

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doi = "10.1111/j.1743-6109.2006.00150.x",

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T1 - A role for decorin in cutaneous wound healing and angiogenesis

AU - Järveläinen, Hannu

AU - Puolakkainen, Pauli

AU - Pakkanen, Sari

AU - Brown, Eric L.

AU - Höök, Magnus

AU - Iozzo, Renato V.

AU - Sage, E. Helene

AU - Wight, Thomas N.

PY - 2006/7

Y1 - 2006/7

N2 - Decorin is known to influence tissue tensile strength and cellular phenotype. Therefore, decorin is likely to have an impact on tissue repair, including cutaneous wound healing. In this study, cutaneous healing of both excisional and incisional full-thickness dermal wounds was studied in decorin-deficient (Dcn-/-) animals. A statistically significant delay in excisional wound healing in the Dcn-/- mice occurred at 4 and 10 days postwounding and, in incisional wounds at 4, 10, and 18 days when compared with wild-type (Dcn-/-) controls. Fibrovascular invasion into polyvinylalcohol sponges was significantly increased by day 18 in Dcn -/- mice relative to Dcn+/+ mice. The 18-day sponge implants in the Dcn-/- mice showed a marked accumulation of biglycan when compared with the corresponding implants in Dcn+/+ mice. Thus, regulated production of decorin may serve as an excellent therapeutic approach for modifying impaired wound healing and harmful foreign body reactions.

AB - Decorin is known to influence tissue tensile strength and cellular phenotype. Therefore, decorin is likely to have an impact on tissue repair, including cutaneous wound healing. In this study, cutaneous healing of both excisional and incisional full-thickness dermal wounds was studied in decorin-deficient (Dcn-/-) animals. A statistically significant delay in excisional wound healing in the Dcn-/- mice occurred at 4 and 10 days postwounding and, in incisional wounds at 4, 10, and 18 days when compared with wild-type (Dcn-/-) controls. Fibrovascular invasion into polyvinylalcohol sponges was significantly increased by day 18 in Dcn -/- mice relative to Dcn+/+ mice. The 18-day sponge implants in the Dcn-/- mice showed a marked accumulation of biglycan when compared with the corresponding implants in Dcn+/+ mice. Thus, regulated production of decorin may serve as an excellent therapeutic approach for modifying impaired wound healing and harmful foreign body reactions.

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AN - SCOPUS:33747610396

SN - 1067-1927

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EP - 452

JO - Wound Repair and Regeneration

JF - Wound Repair and Regeneration

IS - 4

ER -

A role for decorin in cutaneous wound healing and angiogenesis

Abstract

ASJC Scopus subject areas

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