A robust ligand exchange approach for preparing hydrophilic, biocompatible photoluminescent quantum dots

Sujuan Wang, Changhua Zhou, Hang Yuan, Huaibin Shen, Wenxiu Zhao, Lan Ma, Lin Song Li

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

This paper describes a robust ligand exchange approach for preparing biocompatible CdSe/ZnS quantum dots (QDs) to make bioprobe for effective cell imaging. In this method, polymaleic anhydride (PMA) ligand are first used to replace original hydrophobic ligand (oleic acid) and form a protection shell with multiple hydrophilic groups to coat and protect CdSe/ZnS QDs. The as-prepared aqueous QDs exhibit small particle size, good colloidal stability in aqueous solutions with a wide range of pH, salt concentrations and under thermal treatment, which are necessary for biological applications. The use of this new class of aqueous QDs for effective cell imaging shows strong fluorescence signal to human embryonic stem cell, which demonstrate that PMA coated QDs are fully satisfied with the requirements of preparing high quality biological probe.

Original languageEnglish (US)
Pages (from-to)2836-2842
Number of pages7
JournalMaterials Research Bulletin
Volume48
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • A. Polymers
  • A. Semiconductors
  • A. Surfaces
  • B. Chemical synthesis

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

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