A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

William Matthews; Craig T. Jordan; Marc Gavin; Nancy A. Jenkins; Neal G. Copeland; Ihor R. Lemischka

doi:10.1073/pnas.88.20.9026

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

William Matthews, Craig T. Jordan, Marc Gavin, Nancy A. Jenkins, Neal G. Copeland, Ihor R. Lemischka

Research output: Contribution to journal › Article › peer-review

494 Scopus citations

Abstract

We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.

Original language	English (US)
Pages (from-to)	9026-9030
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	20
DOIs	https://doi.org/10.1073/pnas.88.20.9026
State	Published - Oct 15 1991

Keywords

Hematopoietic stem cell
Protein-tyrosine kinase

ASJC Scopus subject areas

General
Genetics

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10.1073/pnas.88.20.9026

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Matthews, W., Jordan, C. T., Gavin, M., Jenkins, N. A., Copeland, N. G., & Lemischka, I. R. (1991). A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proceedings of the National Academy of Sciences of the United States of America, 88(20), 9026-9030. https://doi.org/10.1073/pnas.88.20.9026

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. / Matthews, William; Jordan, Craig T.; Gavin, Marc et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, No. 20, 15.10.1991, p. 9026-9030.

Research output: Contribution to journal › Article › peer-review

Matthews, W, Jordan, CT, Gavin, M, Jenkins, NA , Copeland, NG & Lemischka, IR 1991, 'A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit', Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 20, pp. 9026-9030. https://doi.org/10.1073/pnas.88.20.9026

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A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

Abstract

Keywords

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