TY - JOUR
T1 - A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit
AU - Matthews, William
AU - Jordan, Craig T.
AU - Gavin, Marc
AU - Jenkins, Nancy A.
AU - Copeland, Neal G.
AU - Lemischka, Ihor R.
PY - 1991/10/15
Y1 - 1991/10/15
N2 - We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.
AB - We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.
KW - Hematopoietic stem cell
KW - Protein-tyrosine kinase
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U2 - 10.1073/pnas.88.20.9026
DO - 10.1073/pnas.88.20.9026
M3 - Article
C2 - 1717995
AN - SCOPUS:0025998533
VL - 88
SP - 9026
EP - 9030
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 20
ER -