A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

William Matthews, Craig T. Jordan, Marc Gavin, Nancy A. Jenkins, Neal G. Copeland, Ihor R. Lemischka

Research output: Contribution to journalArticle

439 Scopus citations

Abstract

We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.

Original languageEnglish (US)
Pages (from-to)9026-9030
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number20
DOIs
StatePublished - Oct 15 1991

Keywords

  • Hematopoietic stem cell
  • Protein-tyrosine kinase

ASJC Scopus subject areas

  • General
  • Genetics

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