A randomized clinical trial of ampicillin, gentamicin and clindamycin versus cefotaxime and clindamycin in children with ruptured appendicitis

K. P. Schropp, S. Kaplan, E. S. Golladay, D. R. King, W. Pokorny, D. L. Mollitt, W. E. Wise, E. O. Mason

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

This prospective, randomized, double-blind study compares the efficacy, safety and cost-effectiveness of ampicillin, gentamicin and clindamycin (AGC) or cefotaxime and clindamycin (CC) for the treatment of children with complicated appendicitis. Ninety-seven children were randomized. Forty-seven were assigned to the AGC regimen and 50 received CC. Forty-two patients in the AGC group had an appropriate therapeutic outcome, whereas 48 of 50 children who received CC completed the trial successfully (p=NS). There were no differences between the groups with reference to the duration of antibiotic administration, fever, leukocytosis or length of hospitalization. Complications of therapy were uncommon and neither regimen demonstrated a significant advantage from an economic standpoint. We concluded that, in childhood, complicated appendicitis can be treated with either CC or AGC with equal efficacy.

Original languageEnglish (US)
Pages (from-to)351-356
Number of pages6
JournalSurgery Gynecology and Obstetrics
Volume172
Issue number5
StatePublished - 1991

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'A randomized clinical trial of ampicillin, gentamicin and clindamycin versus cefotaxime and clindamycin in children with ruptured appendicitis'. Together they form a unique fingerprint.

Cite this