A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank

Jon B. Toledo, Vivianna M. Van Deerlin, Edward B. Lee, Eunran Suh, Young Baek, John L. Robinson, Sharon X. Xie, Jennifer McBride, Elisabeth M. Wood, Theresa Schuck, David J. Irwin, Rachel G. Gross, Howard Hurtig, Leo McCluskey, Lauren Elman, Jason Karlawish, Gerard Schellenberg, Alice Chen-Plotkin, David Wolk, Murray GrossmanSteven E. Arnold, Leslie M. Shaw, Virginia M.Y. Lee, John Q. Trojanowski

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein deposits in the central nervous system (CNS), and only neuropathological examination enables a definitive diagnosis. Brain banks and their associated scientific programs have shaped the actual knowledge of NDs, identifying and characterizing the CNS deposits that define new diseases, formulating staging schemes, and establishing correlations between neuropathological changes and clinical features. However, brain banks have evolved to accommodate the banking of biofluids as well as DNA and RNA samples. Moreover, the value of biobanks is greatly enhanced if they link all the multidimensional clinical and laboratory information of each case, which is accomplished, optimally, using systematic and standardized operating procedures, and in the framework of multidisciplinary teams with the support of a flexible and user-friendly database system that facilitates the sharing of information of all the teams in the network. We describe a biobanking system that is a platform for discovery research at the Center for Neurodegenerative Disease Research at the University of Pennsylvania.

Original languageEnglish (US)
Pages (from-to)477-484.e1
JournalAlzheimer's and Dementia
Volume10
Issue number4
DOIs
StatePublished - Jul 2014

Keywords

  • Alzheimer's Disease
  • Autopsy
  • Cerebrospinal fluid
  • Dementia
  • Frontotemporal lobar degeneration
  • Genetics
  • Neurodegeneration
  • Parkinson's Disease
  • Plasma
  • Serum

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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