A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models

Nívea P. Sá; Caroline M. Lima; Julliana R. A Dos Santos; Marliete C. Costa; Patrícia P. De Barros; Juliana C. Junqueira; Jéssica A. Vaz; Renata B. Oliveira; Beth B. Fuchs; Eleftherios Mylonakis; Carlos A. Rosa; Daniel A. Santos; Susana Johann

doi:10.4155/fsoa-2018-0001

A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models

Nívea P. Sá, Caroline M. Lima, Julliana R. A Dos Santos, Marliete C. Costa, Patrícia P. De Barros, Juliana C. Junqueira, Jéssica A. Vaz, Renata B. Oliveira, Beth B. Fuchs, Eleftherios Mylonakis, Carlos A. Rosa, Daniel A. Santos, Susana Johann

Houston Methodist

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Aim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans. Methods: The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models. Results & conclusion: In the present work we verified that CHT is found to inhibit Cryptococcus and C. albicans affecting biofilm in both and inhibited adhesion of Candida to human buccal cells. When we evaluated in vivo, CHT prolonged survival of Galleria mellonella after infections with Cryptococcusgattii, Cryptococcusneoformans or C. albicans and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.

Original language	English (US)
Article number	FSO305
Journal	Future Science OA
Volume	4
Issue number	6
DOIs	https://doi.org/10.4155/fsoa-2018-0001
State	Published - 2018

Keywords

Candida albicans
Cryptococcus spp.
Galleria mellonella
antifungal
mice
thiazole
virulence

ASJC Scopus subject areas

Biotechnology

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Sá, N. P., Lima, C. M., A Dos Santos, J. R., Costa, M. C., De Barros, P. P., Junqueira, J. C., Vaz, J. A., Oliveira, R. B., Fuchs, B. B., Mylonakis, E., Rosa, C. A., Santos, D. A., & Johann, S. (2018). A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models. Future Science OA, 4(6), Article FSO305. https://doi.org/10.4155/fsoa-2018-0001

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abstract = "Aim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans. Methods: The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models. Results & conclusion: In the present work we verified that CHT is found to inhibit Cryptococcus and C. albicans affecting biofilm in both and inhibited adhesion of Candida to human buccal cells. When we evaluated in vivo, CHT prolonged survival of Galleria mellonella after infections with Cryptococcusgattii, Cryptococcusneoformans or C. albicans and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.",

keywords = "Candida albicans, Cryptococcus spp., Galleria mellonella, antifungal, mice, thiazole, virulence",

author = "S{\'a}, {N{\'i}vea P.} and Lima, {Caroline M.} and {A Dos Santos}, {Julliana R.} and Costa, {Marliete C.} and {De Barros}, {Patr{\'i}cia P.} and Junqueira, {Juliana C.} and Vaz, {J{\'e}ssica A.} and Oliveira, {Renata B.} and Fuchs, {Beth B.} and Eleftherios Mylonakis and Rosa, {Carlos A.} and Santos, {Daniel A.} and Susana Johann",

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year = "2018",

doi = "10.4155/fsoa-2018-0001",

language = "English (US)",

volume = "4",

journal = "Future Science OA",

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AU - Sá, Nívea P.

AU - Lima, Caroline M.

AU - A Dos Santos, Julliana R.

AU - Costa, Marliete C.

AU - De Barros, Patrícia P.

AU - Junqueira, Juliana C.

AU - Vaz, Jéssica A.

AU - Oliveira, Renata B.

AU - Fuchs, Beth B.

AU - Mylonakis, Eleftherios

AU - Rosa, Carlos A.

AU - Santos, Daniel A.

AU - Johann, Susana

PY - 2018

Y1 - 2018

N2 - Aim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans. Methods: The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models. Results & conclusion: In the present work we verified that CHT is found to inhibit Cryptococcus and C. albicans affecting biofilm in both and inhibited adhesion of Candida to human buccal cells. When we evaluated in vivo, CHT prolonged survival of Galleria mellonella after infections with Cryptococcusgattii, Cryptococcusneoformans or C. albicans and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.

AB - Aim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans. Methods: The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models. Results & conclusion: In the present work we verified that CHT is found to inhibit Cryptococcus and C. albicans affecting biofilm in both and inhibited adhesion of Candida to human buccal cells. When we evaluated in vivo, CHT prolonged survival of Galleria mellonella after infections with Cryptococcusgattii, Cryptococcusneoformans or C. albicans and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.

KW - Candida albicans

KW - Cryptococcus spp.

KW - Galleria mellonella

KW - antifungal

KW - mice

KW - thiazole

KW - virulence

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A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models

Abstract

Keywords

ASJC Scopus subject areas

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