A phase II trial of paclitaxel and carboplatin in women with advanced or recurrent uterine carcinosarcoma

Robin A. Lacour, Elizabeth Euscher, E. Neely Atkinson, Charlotte C. Sun, Pedro T. Ramirez, Robert L. Coleman, Jubilee Brown, Jacalyn B. Gano, Thomas W. Burke, Lois Michelle Ramondetta

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Background: Systemic therapy for advanced uterine carcinosarcoma (CS) has been disappointing. The most widely studied regimen is ifosfamide and cisplatinum. Moderate success has been documented using paclitaxel in ovarian CS. The purpose of this study was to evaluate carboplatin/paclitaxel in advanced and recurrent uterine CS. Methods: A single-arm, prospective, phase II trial opened in October 2001. Primary end points were time to progression (TTP) and response rate (RR). Quality-of-life data were obtained. Patients treated adjuvantly received 6 cycles of carboplatin/paclitaxel every 21 days. Patients with disease at study entry were treated until response, progression, or toxicity. Results: Of 23 patients enrolled, 9 received adjuvant treatment, 13 had documented disease, 1 was inevaluable. Eight of 13 patients with measurable disease had a complete or partial response (62% RR). Overall, median TTP was 9.5 months. In the adjuvant group, median TTP was 15 months. With measurable disease, median TTP was 7.9 months. Median overall survival was 21.1 months. There was no difference in survival between patients with or without measurable disease. For patients having prior radiation, median TTP with recurrence in the radiated field was 13.3 months, and 14.5 months if outside the field (P = 0.71). Two patients (9%) had treatment-limiting toxicity. Quality-of-life scores improved from baseline over time. Conclusions: Carboplatin and paclitaxel have improved tolerability and RR (62%) compared with previous reports of ifosfamide/cisplatin or ifosfamide/paclitaxel in treating uterine CS. This regimen seems promising and should be considered in combined therapies with targeted agents.

Original languageEnglish (US)
Pages (from-to)517-522
Number of pages6
JournalInternational Journal of Gynecological Cancer
Issue number3
StatePublished - Apr 2011


  • Carboplatin
  • Carcinosarcoma
  • Paclitaxel
  • Uterine

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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