A pharmacokinetic study of GC-1 delivery using a nanochannel membrane device

Carly S. Filgueira, Andrea Ballerini, Eugenia Nicolov, Corrine Ying Xuan Chua, Priya Jain, Zachary W. Smith, April L. Gilbert, Francesco Scaglione, Alessandro Grattoni

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


This study demonstrated a nanochannel membrane device (NMD) for controlled and sustained release of GC-1 in rats, in the context of the treatment of metabolic syndrome. Release profiles were established in vitro both with and without 5% labrasol for over 2 months. In vivo pharmacokinetic evaluation showed effective GC-1 plasma concentrations, which resulted in significant reductions in body weight after just one week of treatment when compared to the NMD releasing vehicle only (PBS). We also provided evidence that rats treated with NMD-GC-1 present sub-active thyroids and clear differences in the morphology of the epithelium and follicles as compared to the controls, while the heart showed changes in weight. Moreover, body temperatures remained stable throughout treatment, and glucose, pancreatic islet size, and liver histology appeared similar between the treated and control groups. Prolonged constant administration of GC-1 from the NMD proved to be a valid strategy to facilitate weight loss.

Original languageEnglish (US)
Pages (from-to)1739-1744
Number of pages6
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Issue number5
StatePublished - Jul 1 2017


  • GC-1 (Sobetirome)
  • Nanochannel membrane device (NMD)
  • Pharmacokinetic
  • Thyroid gland
  • Weight loss

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science


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