A personalized image-guided intervention system for peripheral lung cancer on patient-specific respiratory motion model

Tengfei Wang, Tiancheng He, Zhenglin Zhang, Qi Chen, Liwei Zhang, Guoren Xia, Lizhuang Yang, Hongzhi Wang, Stephen T.C. Wong, Hai Li

Research output: Contribution to journalArticlepeer-review


Purpose: Due to respiratory motion, precise tracking of lung nodule movement is a persistent challenge for guiding percutaneous lung biopsy during image-guided intervention. We developed an automated image-guided system incorporating effective and robust tracking algorithms to address this challenge. Accurate lung motion prediction and personalized image-guided intervention are the key technological contributions of this work. Methods: A patient-specific respiratory motion model is developed to predict pulmonary movements of individual patients. It is based on the relation between the artificial 4D CT and corresponding positions tracked by position sensors attached on the chest using an electromagnetic (EM) tracking system. The 4D CT image of the thorax during breathing is calculated through deformable registration of two 3D CT scans acquired at inspiratory and expiratory breath-hold. The robustness and accuracy of the image-guided intervention system were assessed on a static thorax phantom under different clinical parametric combinations. Results: Real 4D CT images of ten patients were used to evaluate the accuracy of the respiratory motion model. The mean error of the model in different breathing phases was 1.59 ± 0.66 mm. Using a static thorax phantom, we achieved an average targeting accuracy of 3.18 ± 1.2 mm across 50 independent tests with different intervention parameters. The positive results demonstrate the robustness and accuracy of our system for personalized lung cancer intervention. Conclusions: The proposed system integrates a patient-specific respiratory motion compensation model to reduce the effect of respiratory motion during percutaneous lung biopsy and help interventional radiologists target the lesion efficiently. Our preclinical studies indicate that the image-guided system has the ability to accurately predict and track lung nodules of individual patients and has the potential for use in the diagnosis and treatment of early stage lung cancer.

Original languageEnglish (US)
Pages (from-to)1751-1764
Number of pages14
JournalInternational Journal of Computer Assisted Radiology and Surgery
Issue number10
StatePublished - Oct 2022


  • Image registration
  • Image-guided intervention system
  • Patient-specific respiratory motion model
  • Surgical path planning
  • Lung Neoplasms/diagnostic imaging
  • Motion
  • Algorithms
  • Movement
  • Humans
  • Four-Dimensional Computed Tomography/methods
  • Phantoms, Imaging
  • Respiration

ASJC Scopus subject areas

  • Health Informatics
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Surgery
  • Biomedical Engineering
  • Computer Science Applications
  • Computer Graphics and Computer-Aided Design


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