A Persistent Positive Antibody Test in a Patient with No History of COVID-19 Infection

Jordan McMurry, Ezekiel Fink

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Antibody testing for SARS-CoV-2 has been established as a tool with broad utility in the surveillance and control of the COVID-19 pandemic. However, because of limited knowledge about the duration of humoral immunity to COVID-19 and the existence of unique individual immune responses, the potential role of antibody testing in the diagnosis of current and past infections of COVID-19 remains ambiguous. Herein, we describe a unique case of an asymptomatic patient showing a persistent positive total antibody test for SARS-CoV-2 while testing negative for SARS-CoV-2 RNA and IgG-specific antibodies. This case study shows how a combination of tests can be employed to identify a false positive and draw conclusions about a patient's COVID-19 status. It also highlights the complexity of using antibody testing for the diagnosis of COVID-19.

Original languageEnglish (US)
Pages (from-to)E1-E3
JournalLab Medicine
Issue number1
StatePublished - Jan 6 2022


  • COVID-19
  • SARS-CoV-2
  • antibody
  • diagnostics
  • false positive
  • testing
  • Reproducibility of Results
  • Pandemics
  • Humans
  • Immunoglobulin G
  • COVID-19 Serological Testing
  • COVID-19/diagnosis
  • SARS-CoV-2/immunology
  • RNA, Viral
  • Antibodies, Viral/isolation & purification

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'A Persistent Positive Antibody Test in a Patient with No History of COVID-19 Infection'. Together they form a unique fingerprint.

Cite this