A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice

Young Suh Gee; Suk Ham Hyoung; Shin Hye Lee; Chul Choi Jae; Won Jung Koh; Soo Youl Kim; Jongmin Lee; Joungho Han; Pyo Kim Hong; Augustine M.K. Choi; Jung Kwon O

doi:10.1080/01902140600691514

A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice

Young Suh Gee, Suk Ham Hyoung, Shin Hye Lee, Chul Choi Jae, Won Jung Koh, Soo Youl Kim, Jongmin Lee, Joungho Han, Pyo Kim Hong, Augustine M.K. Choi, Jung Kwon O

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α-immunoreactive protein in lung homogenates and significantly decreased TNF-α-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

Original language	English (US)
Pages (from-to)	43-53
Number of pages	11
Journal	Experimental Lung Research
Volume	32
Issue number	1-2
DOIs	https://doi.org/10.1080/01902140600691514
State	Published - Jan 2006

Keywords

Cytokine
Neutrophil
Phospholipase A

ASJC Scopus subject areas

Molecular Biology
Pulmonary and Respiratory Medicine
Clinical Biochemistry

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10.1080/01902140600691514

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title = "A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice",

abstract = "Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α-immunoreactive protein in lung homogenates and significantly decreased TNF-α-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.",

keywords = "Cytokine, Neutrophil, Phospholipase A",

author = "Gee, {Young Suh} and Hyoung, {Suk Ham} and Lee, {Shin Hye} and Jae, {Chul Choi} and Koh, {Won Jung} and Kim, {Soo Youl} and Jongmin Lee and Joungho Han and Hong, {Pyo Kim} and Choi, {Augustine M.K.} and O, {Jung Kwon}",

year = "2006",

month = jan,

doi = "10.1080/01902140600691514",

language = "English (US)",

volume = "32",

pages = "43--53",

journal = "Experimental Lung Research",

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AU - Gee, Young Suh

AU - Hyoung, Suk Ham

AU - Lee, Shin Hye

AU - Jae, Chul Choi

AU - Koh, Won Jung

AU - Kim, Soo Youl

AU - Lee, Jongmin

AU - Han, Joungho

AU - Hong, Pyo Kim

AU - Choi, Augustine M.K.

AU - O, Jung Kwon

PY - 2006/1

Y1 - 2006/1

N2 - Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α-immunoreactive protein in lung homogenates and significantly decreased TNF-α-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

AB - Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α-immunoreactive protein in lung homogenates and significantly decreased TNF-α-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

KW - Cytokine

KW - Neutrophil

KW - Phospholipase A

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JO - Experimental Lung Research

JF - Experimental Lung Research

SN - 0190-2148

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A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice

Abstract

Keywords

ASJC Scopus subject areas

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