A peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice

Young Suh Gee, Suk Ham Hyoung, Shin Hye Lee, Chul Choi Jae, Won Jung Koh, Soo Youl Kim, Jongmin Lee, Joungho Han, Pyo Kim Hong, Augustine M K Choi , Jung Kwon O

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-α-immunoreactive protein in lung homogenates and significantly decreased TNF-α-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.

Original languageEnglish (US)
Pages (from-to)43-53
Number of pages11
JournalExperimental Lung Research
Volume32
Issue number1-2
DOIs
StatePublished - Jan 1 2006

Keywords

  • Cytokine
  • Neutrophil
  • Phospholipase A

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry

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