@inproceedings{0f6bea402e934a878dee3d85705aaa65,
title = "A parametric study of a multiphase porous media model for tumor spheroids and environment interactions",
abstract = "Computational models for tumor growth provide an effective in silico tool to investigate the different stages of cancer growth. Recently, a series of computational models based on porous media theory has been proposed to predict tumor evolution and its interactions with the host tissue. In addition, a specialization of the original models, adapted for tumor spheroids, has been proposed and validated experimentally. However, due to the complexity of the modeling framework, a systematic understanding of the role of the parameters governing the equations is still lacking. In this work, we perform a parametric analysis on a set of fundamental parameters appearing in the model equations. We investigate the effects of a variation of these coefficients on the spheroid growth curves and, in particular, on the final radii reached by the cell aggregates in the growth saturation stage. Finally, we provide a discussion of the results and give a brief summary of our findings.",
keywords = "Cancer growth, Growth inhibition, Mathematical modeling, Mechanical compression of spheroids, Parametric analysis, U-87mg spheroids",
author = "P. Mascheroni and Boso, {D. P.} and C. Stigliano and M. Carfagna and L. Preziosi and P. Decuzzi and Schrefler, {B. A.}",
year = "2016",
doi = "10.7712/100016.1802.12118",
language = "English (US)",
series = "ECCOMAS Congress 2016 - Proceedings of the 7th European Congress on Computational Methods in Applied Sciences and Engineering",
publisher = "National Technical University of Athens",
pages = "178--187",
editor = "G. Stefanou and V. Papadopoulos and V. Plevris and M. Papadrakakis",
booktitle = "ECCOMAS Congress 2016 - Proceedings of the 7th European Congress on Computational Methods in Applied Sciences and Engineering",
note = "7th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2016 ; Conference date: 05-06-2016 Through 10-06-2016",
}