@article{e8e6279a114e494ea1540794d71815ec,
title = "A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination",
abstract = "The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and therapeutic strategies, and both are still insufficient. Here, we describe an ultrathin two-dimensional CuInP2S6 (CIPS) nanosheet as a new agent against SARS-CoV-2 infection. CIPS exhibits an extremely high and selective binding capacity (dissociation constant (KD) < 1 pM) for the receptor binding domain of the spike protein of wild-type SARS-CoV-2 and its variants of concern, including Delta and Omicron, inhibiting virus entry and infection in angiotensin converting enzyme 2 (ACE2)-bearing cells, human airway epithelial organoids and human ACE2-transgenic mice. On association with CIPS, the virus is quickly phagocytosed and eliminated by macrophages, suggesting that CIPS could be successfully used to capture and facilitate virus elimination by the host. Thus, we propose CIPS as a promising nanodrug for future safe and effective anti-SARS-CoV-2 therapy, and as a decontamination agent and surface-coating material to reduce SARS-CoV-2 infectivity.",
author = "Guofang Zhang and Yalin Cong and Liu, {Feng Liang} and Jiufeng Sun and Jiantian Zhang and Guoli Cao and Lingqiang Zhou and Wenjie Yang and Qingle Song and Fangjun Wang and Ke Liu and Jing Qu and Jing Wang and Min He and Shun Feng and Didar Baimanov and Wei Xu and Luo, {Rong Hua} and Long, {Xin Yan} and Shumin Liao and Yunping Fan and Li, {Yu Feng} and Bai Li and Ximing Shao and Guocheng Wang and Lijing Fang and Huaiyu Wang and Yu, {Xue Feng} and Chang, {Yan Zhong} and Yuliang Zhao and Liang Li and Peng Yu and Zheng, {Yong Tang} and Diana Boraschi and Hongchang Li and Chunying Chen and Liming Wang and Yang Li",
note = "Funding Information: The authors are grateful to D. Li, J. Nahar, K. Chen, T. Liu, X. Li, X. Lin, Y. Wang, Y. Qiu and Y. Zeng (Laboratory of Immunology and Nanomedicine of SIAT-CAS) for their kind help with the biosafety experiment, to K. Liu (IHEP), R. Qiao (NCNST) and X. Li (IHEP) for their kind help with ICP-MS/XRF/XAFS experiments, and to Boyubio Company for assistance with the MD simulations. The authors also acknowledge the support from the Directional Institutionalized Scientific Research Platform of Beijing Synchrotron Radiation Facility of CAS, and the technological support from the biological MS facility of Dalian Coherent Light Source and Kunming National High-Level Biosafety Research Center for Non-human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, CAS. This work was financially supported by the National Key R&D Program of China (grant nos. 2021YFE0113000 (to Y.L., F.-L.L. and G.W.), 2021YFA1200900 (to L.W. and C.C.) and 2020YFA0710702 (to L.W.)), the National Natural Science Foundation of China (grant nos. 32171390 (to Y.L.), 31971322 (to L.W.), 22027810 and 11621505 (to C.C.), and 32088101 (to F.W.)), the CAS International Partnership Program (grant no. 172644KYSB20210011 (to Y.L.)), the CAS Strategic Priority Research Program (grant no. XDB36000000 (to C.C.)), the Chinese Academy of Medical Sciences Innovation Fund for Medical Science (grant no. CIFMS 2019-I2M-5-018 (to C.C.)), the National Natural Science Foundation of Guangdong Province (grant nos. 2022A1515010549 (to Y.L.) and 2021B1212030007 (to J.S.)), the Research and Development Project in Key Areas of Guangdong Province (grant no. 2019B090917011 (to C.C.)), the Shenzhen Science and Technology Program (grant nos. GJHZ20190821155803877 (to Y.L.) and JCYJ20210324120200001 (to H.L.)), the Research and Development Project in Key Areas of Guangzhou (grant no. 202008070007 (to C.C.)), the Science and Technology Innovation Project of IHEP (grant no. E25459U210 (to L.W.)), the CAS President{\textquoteright}s International Fellowship Initiative (grant nos. 2022VBA0008 and 2021PB0060 (to Y.L.), and 2021PM0059 (to L.W.)), the Beijing Municipal Health Commission (grant no. 2021-1G-1191 (to L.W.)) and the State Key Laboratory of Natural and Biomimetic Drugs, Peking University (grant no. K202001 (to L.W.)). Funding Information: The authors are grateful to D. Li, J. Nahar, K. Chen, T. Liu, X. Li, X. Lin, Y. Wang, Y. Qiu and Y. Zeng (Laboratory of Immunology and Nanomedicine of SIAT-CAS) for their kind help with the biosafety experiment, to K. Liu (IHEP), R. Qiao (NCNST) and X. Li (IHEP) for their kind help with ICP-MS/XRF/XAFS experiments, and to Boyubio Company for assistance with the MD simulations. The authors also acknowledge the support from the Directional Institutionalized Scientific Research Platform of Beijing Synchrotron Radiation Facility of CAS, and the technological support from the biological MS facility of Dalian Coherent Light Source and Kunming National High-Level Biosafety Research Center for Non-human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, CAS. This work was financially supported by the National Key R&D Program of China (grant nos. 2021YFE0113000 (to Y.L., F.-L.L. and G.W.), 2021YFA1200900 (to L.W. and C.C.) and 2020YFA0710702 (to L.W.)), the National Natural Science Foundation of China (grant nos. 32171390 (to Y.L.), 31971322 (to L.W.), 22027810 and 11621505 (to C.C.), and 32088101 (to F.W.)), the CAS International Partnership Program (grant no. 172644KYSB20210011 (to Y.L.)), the CAS Strategic Priority Research Program (grant no. XDB36000000 (to C.C.)), the Chinese Academy of Medical Sciences Innovation Fund for Medical Science (grant no. CIFMS 2019-I2M-5-018 (to C.C.)), the National Natural Science Foundation of Guangdong Province (grant nos. 2022A1515010549 (to Y.L.) and 2021B1212030007 (to J.S.)), the Research and Development Project in Key Areas of Guangdong Province (grant no. 2019B090917011 (to C.C.)), the Shenzhen Science and Technology Program (grant nos. GJHZ20190821155803877 (to Y.L.) and JCYJ20210324120200001 (to H.L.)), the Research and Development Project in Key Areas of Guangzhou (grant no. 202008070007 (to C.C.)), the Science and Technology Innovation Project of IHEP (grant no. E25459U210 (to L.W.)), the CAS President{\textquoteright}s International Fellowship Initiative (grant nos. 2022VBA0008 and 2021PB0060 (to Y.L.), and 2021PM0059 (to L.W.)), the Beijing Municipal Health Commission (grant no. 2021-1G-1191 (to L.W.)) and the State Key Laboratory of Natural and Biomimetic Drugs, Peking University (grant no. K202001 (to L.W.)). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2022",
month = sep,
doi = "10.1038/s41565-022-01177-2",
language = "English (US)",
volume = "17",
pages = "993--1003",
journal = "Nature Nanotechnology",
issn = "1748-3387",
publisher = "Nature Publishing Group",
number = "9",
}