A nanocomplex system as targeted contrast agent delivery vehicle for magnetic resonance imaging dynamic contrast enhancement study

Alexandru Korotcov, Liang Shan, Huan Meng, Tongxin Wang, Rajagopalan Sridhar, Yuliang Zhao, Xing Jie Liang, Paul C. Wang

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We have developed and tested a liposomal nanocomplex system, which contains Gd-DTPA as a payload and transferrin on the surface, as a tumor specific targeting MRI contrast agent for studying prostate cancer tumors in mice. In vivo, the probe significantly enhanced the MRI signal. The image contrast between the peripheral region of the tumor and the non-involved muscle was nearly 50% higher two hours after administration of the nanocomplex. The liposomal nanocomplex increased the amount of Gd accumulated in tumors by factor 2.8 compared to that accumulated by using Magnevist alone. Moreover, the heterogeneous MRI image features correlate well with the tumor pathology. The image enhancement patterns can be used for cancer prognosis and non-invasive monitoring of the response to therapy.

Original languageEnglish (US)
Pages (from-to)7545-7549
Number of pages5
JournalJournal of Nanoscience and Nanotechnology
Volume10
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • Cancer
  • Dynamic contrast enhancement (DCE)-MRI
  • Liposome
  • Nanoparticle
  • Targeted drug delivery
  • Transferrin

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

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