A Multiscale Model of Atherosclerotic Plaque Development: Toward a Coupling Between an Agent-Based Model and CFD Simulations

Anna Corti, Stefano Casarin, Claudio Chiastra, Monika Colombo, Francesco Migliavacca, Marc Garbey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Computational models have been widely used to predict the efficacy of surgical interventions in response to Peripheral Occlusive Diseases. However, most of them lack a multiscale description of the development of the disease, which, in our hypothesis, is the key to develop an effective predictive model. Accordingly, in this work we present a multiscale computational framework that simulates the generation of atherosclerotic arterial occlusions. Starting from a healthy artery in homeostatic conditions, the perturbation of specific cellular and extracellular dynamics led to the development of the pathology, with the final output being a diseased artery. The presented model was developed on an idealized portion of a Superficial Femoral Artery (SFA), where an Agent-Based Model (ABM), locally replicating the plaque development, was coupled to Computational Fluid Dynamics (CFD) simulations that define the Wall Shear Stress (WSS) profile at the lumen interface. The ABM was qualitatively validated on histological images and a preliminary analysis on the coupling method was conducted. Once optimized the coupling method, the presented model can serve as a predictive platform to improve the outcome of surgical interventions such as angioplasty and stent deployment.

Original languageEnglish (US)
Title of host publicationComputational Science – ICCS 2019 - 19th International Conference, Proceedings
EditorsJoão M.F. Rodrigues, Pedro J.S. Cardoso, Jânio Monteiro, Roberto Lam, Valeria V. Krzhizhanovskaya, Michael H. Lees, Peter M.A. Sloot, Jack J. Dongarra
PublisherSpringer-Verlag
Pages410-423
Number of pages14
ISBN (Print)9783030227463
DOIs
StatePublished - Jan 1 2019
Event19th International Conference on Computational Science, ICCS 2019 - Faro, Portugal
Duration: Jun 12 2019Jun 14 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11539 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other19th International Conference on Computational Science, ICCS 2019
CountryPortugal
CityFaro
Period6/12/196/14/19

Keywords

  • Agent-Based Model
  • Atherosclerosis
  • Computational Fluid Dynamics
  • Multiscale model
  • Peripheral Occlusive Diseases

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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