A multifunctional nanostructured platform for localized sustained release of analgesics and antibiotics

Matthew B. Murphy, S. M. Khaled, Dongmei Fan, Iman K. Yazdi, Michael Sprintz, Rachel M. Buchanan, Christine A. Smid, Bradley K. Weiner, Mauro Ferrari, Ennio Tasciotti

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The current delivery methods for pain medication, local anesthetics, antibiotics, and steroids present several limitations mainly due to their route of administration, which results in suboptimal pain management, potential systemic toxicity, and subtherapeutic levels which increases the risk of microorganisms developing antibiotic resistance. Our group developed a hybrid material consisting of nanoporous silicon (pSi) and poly(lactic-co-glycolic acid) (PLGA) nanoparticles, loaded with antibiotics and pain relief medications, respectively. The medications were delivered via a bioactive angiogenic gel of platelet-rich plasma (PRP). This system releases both molecules in a sustained and controlled fashion while simultaneously promoting wound healing and vascularization of the surgical site. The resulting advantages include improved medication efficacy at a lower total drug concentration, decreased risk of systemic toxicity, and for antibiotics, decreased risk of developing resistance. The versatile nature of our platform allows for a variety of different drugs, molecules, biological factors to be loaded and released by the gel. Moreover, by tuning the chemical and physical properties of each component, it is possible to tailor the release rate of each biomolecule to its desired therapeutic level. Therapeutic and antimicrobial agents were released at potent daily dosages for up to 7. days by combination of PLGA and pSi particles free or embedded within the PRP gel. When implanted in vivo, the composite gel was vascularized and infiltrated with endogenous cells by 2. weeks while exhibiting no symptoms of inflammation or immune response. This novel technology has the potential to dramatically affect the post-operative management of patients with an immediate improvement in post-operative pain management, decreased PACU and hospital length of stays, with subsequently decreased hospital and surgical costs. Furthermore, this unique and effective drug delivery platform technology may eliminate the need for subsequent treatments, repeat dosing, and dramatically improve patient convenience and patient compliance.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalEuropean Journal of Pain Supplements
Volume5
Issue number2
DOIs
StatePublished - Nov 2011

Keywords

  • Controlled release
  • Drug delivery
  • Nanomedicine
  • Platelet-rich plasma

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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