A multifaceted role for MOF histone modifying factor in genome maintenance

Kalpana Mujoo, Clayton R. Hunt, Nobuo Horikoshi, Tej K. Pandita

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

MOF (males absent on the first) was initially identified as a dosage compensation factor in Drosophila that acetylates lysine 16 of histone H4 (H4K16ac) and increased gene transcription from the single copy male X-chromosome. In humans, however, the ortholog of Drosophila MOF has been shown to interact with a range of proteins that extend its potential significance well beyond transcription. For example, recent results indicate MOF is an upstream regulator of the ATM (ataxia-telangiectasia mutated) protein, the loss of which is responsible for ataxia telangiectasia (AT). ATM is a key regulatory kinase that interacts with and phosphorylates multiple substrates that influence critical, cell-cycle control and DNA damage repair pathways in addition to other pathways. Thus, directly or indirectly, MOF may be involved in a wide range of cellular functions. This review will focus on the contribution of MOF to cellular DNA repair and new results that are beginning to examine the in vivo physiological role of MOF.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalMechanisms of Ageing and Development
Volume161
DOIs
StatePublished - Jan 1 2017

Keywords

  • DNA DSB
  • H4K16ac
  • HR
  • MOF
  • NHEJ
  • Oncogenesis

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Fingerprint Dive into the research topics of 'A multifaceted role for MOF histone modifying factor in genome maintenance'. Together they form a unique fingerprint.

Cite this