A multifaceted role for ATM in genome maintenance

The pleiotropic nature of the clinical phenotypes of patients with ataxia-telangiectasia (A-T)-which encompass cerebellar degeneration (leading to ataxia), gonadal atrophy, and cancer predisposition-suggests multiple functions of the gene responsible for the disease. The ataxia-telangiectasia mutated gene product (ATM), whose loss of function is responsible for ataxia-telangiectasia, is a protein kinase that interacts with several substrates and is implicated in mitogenic signal transduction, chromosome condensation, meiotic recombination, cell-cycle control and telomere maintenance. This review focuses on the critical roles that ATM appears to play in cell-cycle checkpoints, DNA repair, telomere metabolism and oxidative stress, indicating how defects in these processes might lead to ataxia-telangiectasia.