TY - JOUR
T1 - A multi-scale computational model for the passive mechanical behavior of right ventricular myocardium
AU - Li, David S.
AU - Mendiola, Emilio A.
AU - Avazmohammadi, Reza
AU - Sachse, Frank B.
AU - Sacks, Michael S.
N1 - Funding Information:
This work was supported by the National Institutes of Health, United States ( T32 EB007507 to D.S.L., K99 HL138288 to R.A., R01 HL094464 to F.B.S., R01 HL063954 to M.S.S.).
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/6
Y1 - 2023/6
N2 - We have previously demonstrated the importance of myofiber–collagen mechanical interactions in modeling the passive mechanical behavior of right ventricle free wall (RVFW) myocardium. To gain deeper insights into these coupling mechanisms, we developed a high-fidelity, micro-anatomically realistic 3D finite element model of right ventricle free wall (RVFW) myocardium by combining high-resolution imaging and supercomputer-based simulations. We first developed a representative tissue element (RTE) model at the sub-tissue scale by specializing the hyperelastic anisotropic structurally-based constitutive relations for myofibers and ECM collagen, and equi-biaxial and non-equibiaxial loading conditions were simulated using the open-source software FEniCS to compute the effective stress–strain response of the RTE. To estimate the model parameters of the RTE model, we first fitted a ’top-down’ biaxial stress–strain behavior with our previous structurally based (tissue-scale) model, informed by the measured myofiber and collagen fiber composition and orientation distributions. Next, we employed a multi-scale approach to determine the tissue-level (5 x 5 x 0.7 mm specimen size) RVFW biaxial behavior via ’bottom-up’ homogenization of the fitted RTE model, recapitulating the histologically measured myofiber and collagen orientation to the biaxial mechanical data. Our homogenization approach successfully reproduced the tissue-level mechanical behavior of our previous studies in all biaxial deformation modes, suggesting that the 3D micro-anatomical arrangement of myofibers and ECM collagen is indeed a primary mechanism driving myofiber–collagen interactions.
AB - We have previously demonstrated the importance of myofiber–collagen mechanical interactions in modeling the passive mechanical behavior of right ventricle free wall (RVFW) myocardium. To gain deeper insights into these coupling mechanisms, we developed a high-fidelity, micro-anatomically realistic 3D finite element model of right ventricle free wall (RVFW) myocardium by combining high-resolution imaging and supercomputer-based simulations. We first developed a representative tissue element (RTE) model at the sub-tissue scale by specializing the hyperelastic anisotropic structurally-based constitutive relations for myofibers and ECM collagen, and equi-biaxial and non-equibiaxial loading conditions were simulated using the open-source software FEniCS to compute the effective stress–strain response of the RTE. To estimate the model parameters of the RTE model, we first fitted a ’top-down’ biaxial stress–strain behavior with our previous structurally based (tissue-scale) model, informed by the measured myofiber and collagen fiber composition and orientation distributions. Next, we employed a multi-scale approach to determine the tissue-level (5 x 5 x 0.7 mm specimen size) RVFW biaxial behavior via ’bottom-up’ homogenization of the fitted RTE model, recapitulating the histologically measured myofiber and collagen orientation to the biaxial mechanical data. Our homogenization approach successfully reproduced the tissue-level mechanical behavior of our previous studies in all biaxial deformation modes, suggesting that the 3D micro-anatomical arrangement of myofibers and ECM collagen is indeed a primary mechanism driving myofiber–collagen interactions.
KW - Finite element modeling
KW - Image based modeling
KW - Myocardium mechanics
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U2 - 10.1016/j.jmbbm.2023.105788
DO - 10.1016/j.jmbbm.2023.105788
M3 - Article
C2 - 37060716
AN - SCOPUS:85153493778
VL - 142
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
SN - 1751-6161
M1 - 105788
ER -